MODULATION OF SOMATOSENSORY TRANSMISSION DURING MOVEMENT

这项调查解决了需要定义的神经回路 大脑处理不同类型躯体感觉的机制 在实际的行为情况下，特别是在 四肢的活跃运动。 作为一个例子，PI描述了 一种现象，其中躯体感觉输入到初级躯体感觉 大鼠的皮层根据到达触摸的阶段进行修改 前肢的运动。 在这一点上，皮肤的感觉输入从 投射到特定类别的皮质神经元的前爪是门控的， 根据是否在禁食期间递送刺激来门控 肢体朝向目标的运动，或在触摸目标期间 本身 这些研究将继续确定 在这种感觉门控发生的躯体感觉系统中， 前肢自发或操作性条件运动的背景 或者胡须 运动皮层和其他偏置的可能作用 也将审查可能在这一现象中发挥作用的来源。 新技术 用于在CNS的多个水平记录多个单个单元， 在这些研究中使用。

This investigation addresses the need to define the neural circuit mechanisms by which the brain processes different types of somesthetic sensory information during actual behavioral situations, especially during active movements of the limbs. As an example of this, the PI has described a phenomenon in which somatic sensory input to the primary somatosensory cortex of the rat is modified according to the phases of reach-to-touch movements of the forelimb. In this, cutaneous sensory inputs from the forepaw projecting to specific classes of cortical neurons are gated-in or gated-out according to whether the stimulation is delivered during the fast movement of the limb toward a target, or during the touch of the target itself. These studies will continue to define the sites in the somatosensory system at which this sensory gating is occurring, in the context of spontaneous or operantly conditioned movements of the forelimb or the whiskers. The possible role that the motor cortex and other biasing sources may play in this phenomenon will also be examined. New techniques for recording multiple single units at multiple levels of the CNS will be employed in these studies.