MODULATION OF SOMATOSENSORY TRANSMISSION IN MOVEMENT

运动中体感传输的调节

• 批准号: 6187209
• 负责人: JOHN King CHAPIN
• 金额: $ 25.22万
• 依托单位: SUNY DOWNSTATE MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 1988
• 资助国家: 美国
• 起止时间: 1988-12-01 至 2003-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6187209
• 关键词: afferent nerve; brain electrical activity; brain mapping; electrophysiology; laboratory rat; limb movement; motor cortex; neural information processing; neural transmission; operant conditionings; sensorimotor system; sensory feedback; somesthesis; somesthetic sensory cortex; spinal trigeminal nucleus; vibrissae

DESCRIPTION: The overall aim of this project is to elucidate the neural circuit mechanisms underlying the brain's ability to control its own sensory input. To address this issue, large number of single neurons (up to 128) will be recorded simultaneously through multi-electrode arrays implanted in multiple processing levels of the trigeminal somatosensory system of awake rates, during immobility and will performing exploratory wwhisking movements. Simultaneous recordings have recently been obtained in the trigeminal ganglion (Vg), principal (PrV) and spinal SpV) trigeminal nuclei, ventral posteromedial (VPM) thalamus, and somatosensory (SI) cortex. Aim #1 is to continue current studies of spatiotemporally distributed "shifting" receptive fields in neurons in the VPM and SI, which appear to be learned through motor experience. Aim #2 is to determine whether active whisker movement produces and "efference copy" which modulates sensory transmission according to the phase and "motor intention" of the movement. Aim #3 is to record from the same neurons in rats trained to discriminate among several tactile objects using active whisking.

描述：该项目的总体目标是阐明神经网络 大脑控制自身能力的电路机制 感觉输入。 为了解决这个问题，大量的单个神经元 （最多128个）将通过多电极同时记录 阵列植入三叉神经的多个处理层 清醒率、静止状态和意志状态的体感系统 进行探索性的 wwisking 动作。 同时录音有 最近在三叉神经节 (Vg)、主神经节 (PrV) 中获得 和脊髓 SpV）三叉神经核，腹侧后内侧（VPM）丘脑， 和体感（SI）皮层。 目标#1是继续当前的研究 神经元中时空分布的“移动”感受野 VPM 和 SI 似乎是通过运动经验学习的。 目标#2是确定活跃的胡须运动是否产生和 “效果复制”根据 运动的阶段和“运动意图”。 目标 #3 是记录 老鼠身上的相同神经元经过训练可以区分几种触觉 使用主动搅拌的物体。

项目成果

Neonatal whisker removal in rats stabilizes a transient projection from the auditory thalamus to the primary somatosensory cortex.

去除大鼠新生胡须可稳定从听觉丘脑到初级体感皮层的短暂投射。

• DOI: 10.1016/0006-8993(91)91445-7
• 发表时间: 1991
• 期刊: Brain research
• 影响因子: 2.9
• 作者: Nicolelis,MA;Chapin,JK;Lin,RC
• 通讯作者: Lin,RC

The estrous cycle and the olivo-cerebellar circuit. I. Contrast enhancement of sensorimotor-correlated cerebellar discharge.

发情周期和橄榄小脑回路。

• DOI: 10.1007/bf00228726
• 发表时间: 1996
• 期刊: Experimental brain research
• 影响因子: 2
• 作者: Smith,SS;Chapin,JK
• 通讯作者: Chapin,JK

Mapping the effects of SI cortex stimulation on somatosensory relay neurons in the rat thalamus: direct responses and afferent modulation.

绘制 SI 皮层刺激对大鼠丘脑体感中继神经元的影响：直接反应和传入调节。

• DOI: 10.3109/08990229009144717
• 发表时间: 1990
• 期刊: Somatosensory & motor research
• 影响因子: 0.9
• 作者: Shin,HC;Chapin,JK
• 通讯作者: Chapin,JK

Impact of neuroprosthetic applications on functional recovery.

神经假体应用对功能恢复的影响。

• DOI: 10.1016/s0079-6123(00)28011-4
• 发表时间: 2000
• 期刊: Progress in brain research
• 作者: Chapin,JK

Spatiotemporal structure of somatosensory responses of many-neuron ensembles in the rat ventral posterior medial nucleus of the thalamus.

大鼠丘脑腹侧后内侧核多神经元群体感反应的时空结构。

• DOI: 10.1523/jneurosci.14-06-03511.1994
• 发表时间: 1994
• 期刊: The Journal of neuroscience : the official journal of the Society for Neuroscience
• 作者: Nicolelis,MA;Chapin,JK
• 通讯作者: Chapin,JK