MODULATION OF SOMATOSENSORY TRANSMISSION IN MOVEMENT

描述：本项目的总体目标是阐明神经 大脑控制自身神经回路的能力 感官输入 为了解决这个问题，大量的单个神经元 (up到128）将通过多电极同时记录 植入三叉神经的多个处理水平的阵列 清醒率的躯体感觉系统，在不动和意志 进行探索性的挥动动作。 同时录音有 最近获得的三叉神经节（Vg），主要（PrV） 和脊髓SpV）三叉神经核，腹后内侧（VPM）丘脑， 和躯体感觉（SI）皮层。 目标#1是继续目前的研究 时空分布的“移动”感受野的神经元 在VPM和SI，这似乎是通过运动经验学习。 目的#2是确定主动胡须运动是否产生和 “传出复制”，根据 运动的相位和“运动意图”。 目标#3是记录 同样的神经元在老鼠中被训练来区分几种触觉， 使用主动拂动的对象。

DESCRIPTION: The overall aim of this project is to elucidate the neural circuit mechanisms underlying the brain's ability to control its own sensory input. To address this issue, large number of single neurons (up to 128) will be recorded simultaneously through multi-electrode arrays implanted in multiple processing levels of the trigeminal somatosensory system of awake rates, during immobility and will performing exploratory wwhisking movements. Simultaneous recordings have recently been obtained in the trigeminal ganglion (Vg), principal (PrV) and spinal SpV) trigeminal nuclei, ventral posteromedial (VPM) thalamus, and somatosensory (SI) cortex. Aim #1 is to continue current studies of spatiotemporally distributed "shifting" receptive fields in neurons in the VPM and SI, which appear to be learned through motor experience. Aim #2 is to determine whether active whisker movement produces and "efference copy" which modulates sensory transmission according to the phase and "motor intention" of the movement. Aim #3 is to record from the same neurons in rats trained to discriminate among several tactile objects using active whisking.