MODULATION OF SOMATOSENSORY TRANSMISSION IN MOVEMENT

运动中体感传输的调节

• 批准号: 2891735
• 负责人: JOHN King CHAPIN
• 金额: $ 24.25万
• 依托单位: MCP HAHNEMANN UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1988
• 资助国家: 美国
• 起止时间: 1988-12-01 至 2000-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2891735
• 关键词: afferent nerve; brain electrical activity; brain mapping; electrophysiology; laboratory rat; limb movement; motor cortex; neural information processing; neural transmission; operant conditionings; sensorimotor system; sensory feedback; somesthesis; somesthetic sensory cortex; spinal trigeminal nucleus; vibrissae

DESCRIPTION: The overall aim of this project is to elucidate the neural circuit mechanisms underlying the brain's ability to control its own sensory input. To address this issue, large number of single neurons (up to 128) will be recorded simultaneously through multi-electrode arrays implanted in multiple processing levels of the trigeminal somatosensory system of awake rates, during immobility and will performing exploratory wwhisking movements. Simultaneous recordings have recently been obtained in the trigeminal ganglion (Vg), principal (PrV) and spinal SpV) trigeminal nuclei, ventral posteromedial (VPM) thalamus, and somatosensory (SI) cortex. Aim #1 is to continue current studies of spatiotemporally distributed "shifting" receptive fields in neurons in the VPM and SI, which appear to be learned through motor experience. Aim #2 is to determine whether active whisker movement produces and "efference copy" which modulates sensory transmission according to the phase and "motor intention" of the movement. Aim #3 is to record from the same neurons in rats trained to discriminate among several tactile objects using active whisking.

描述：这个项目的总体目标是阐明神经 大脑控制自身的能力背后的电路机制 感官输入。为了解决这个问题，大量的单个神经元 (最多128个)将通过多个电极同时记录 植入三叉神经多个处理节段的阵列 静止和意志状态下觉醒的躯体感觉系统 表演探索性的挥舞动作。同步录音有 最近在三叉神经节(VG)、主神经节(PRV)获得 和脊髓SPV)、三叉神经核、丘脑腹后内侧核、 和体感(SI)皮层。第一个目标是继续目前的研究 神经元中时空分布的“移位”感受野 在VPM和SI中，这似乎是通过运动经验学习的。 目标2是确定活跃的胡须运动是否会产生和 “传出复制”，它根据感官传递的 运动的阶段和“运动意图”。目标3是从 训练大鼠区分几种触觉的相同神经元 使用主动搅拌的对象。