ENVIRONMENTAL/BEHAVIORAL INTERACTIONS AND DRUG TAKING

这是对ADAMHA Research的持续支持的请求 科学家奖。计划的长远目标和具体目标 拟议的研究侧重于可概括知识的发展 与寻求毒品的环境和行为决定因素有关 和吸毒，因为这些过程关系到公共卫生问题 与药物依赖和滥用有关。 更具体地说，拟议的调查将强调 补、辨、补的实验研究 滥用药物的生理依赖产生特性 实验室灵长类动物，特别是最常被虐待的 镇静/催眠/缓解焦虑和刺激剂(例如，苯二氮类药物， 安非他命、可卡因)。静脉和口服两种途径 将研究给药，分子作用机制将是 调查过了。 此外，当局亦会进行调查，以确定 以及此类药物对感觉和运动功能的慢性影响 单项滥用和联合滥用，以形成适当的 实验室灵长类动物行为毒性数据库。这些研究将 涉及动物心理物理方法的应用和扩展 评价药物对听觉和视觉阈值、反应的影响 和元音辨别功能。 还将进行研究，以探索决定因素和 在全球范围内寻求和吸毒对人类志愿者的影响 一个连续规划的住宅实验室的背景 小规模特定社会系统的实验分析 强调被虐待的动机和表现的影响 在这种条件下的物质(如大麻)。 这几个方面之间的相互关系 科学探究和拟议研究的长期目标 加强与潜在药物依赖有关的知识库，并 滥用责任应在统一的概念中理解 环境/生物行为模型的框架，用于集成 多个相互作用的调查工作层面侧重于 寻找毒品和吸毒是公共卫生的关键方面 担忧。

This is a request for continued support of an ADAMHA Research Scientist Award. The long-term objectives and specific aims of the proposed research focus upon the development of generalizable knowledge relevant to the environmental and behavioral determinants of drug-seeking and drug-taking as these processes bear upon public health concerns related to drug dependence and abuse. More specifically, the proposed investigations will emphasize experimental studies of the reinforcing, discriminative, and physiological dependence-producing properties of drugs of abuse in laboratory primates with particular reference to the most commonly abused sedative/hypnotic/anxiolytic and stimulant agents (e.g., benzodiazepines, amphetamines, cocaine). Both intravenous and oral routes of administration will be studied and molecular mechanisms of action will be investigated. Investigations will also be undertaken to determine the acute and chronic effects upon sensory and motor functions of such drugs of abuse both singly and in combination so as to develop an appropriate behavioral toxicity data base in laboratory primates. These studies will involve applications and extensions of animal psychophysical methods for assessment of drug effects upon auditory and visual thresholds, reaction times, and vowel discrimination functions. Studies will also be undertaken to explore the determinants and consequences of drug-seeking and drug-taking in human volunteers within the context of a continuously programmed residential laboratory for the experimental analysis of small scale social systems with particular emphasis upon the motivational and performance effects of abused substances (e.g. marijuana) under such conditions. The interrelationships between these several aspects of scientific inquiry and the longterm objectives of the proposed research to enhance the knowledge base relevant to drug dependence potential and abuse liability is to be understood within the unifying conceptual framework of an environmental/biobehavioral model for integrating the multiple interacting levels of investigative effort focused upon drug-seeking and drug-taking as critical aspects of public health concern.