RAT MODEL FOR TREATMENT OF COCAINE ADDICTION

本合同的目的是确定可卡因自身的参数 在似乎是人类可卡因成瘾模型的大鼠身上给药。 由于可卡因成瘾是一种多方面的疾病， 成分(唤醒、渴望、寻求毒品、吸毒、奖励、 禁欲、戒断、复发和康复)，基本目标是 进一步了解这些行为状态，并尝试确定 近似这些状态中的每一种状态的范例。例如，使用 出现了承包商在大鼠身上开发的离散试验程序 类似于人类吸毒行为的周期性。今年5月 更接近于可卡因中常见的狂欢模式 施虐者。 这项工作将包括研究人体内的基本神经递质系统。 大脑，并将利用现有药物和新的实验化合物来 更改这些发射机系统。例如，多巴胺的作用， 将对5-羟色胺或其他内源性胺进行研究。这只动物 模型将利用可卡因自身的累进比率表 管理，具有并发、顺序或并行秒数 增强剂(食物或水保持的时间表)，以评估一般 老鼠的情况。预计有八到十二种化合物 将每年在基本的几个范式中的每一个中进行研究 由承包商设计的模型。这些化合物将被分配给 由项目官员提供。

The object of this contract is to establish parameters for cocaine self- administration in rats which appear to model cocaine addiction in man. Since cocaine addiction is a multifaceted illness with different components (arousal, craving, drug-seeking, drug-taking, reward, abstinence, withdrawal, relapse, and recovery), the basic aim is to further understand each of these behavioral states and attempt to identify paradigms that approximate each of these states. For example, the use of a discrete trials procedure in rats developed by the contractor appears similar to the cyclic nature of drug taking behaviors in man. This may more closely approximate the binging pattern that is often seen in cocaine abusers. The work will involve studying basic neurotransmitter systems in the brain, and will utilize existing drugs and new experimental compounds to alter these transmitter systems. For example, the role of dopamine, serotonin, or other endogenous amines will be investigated. The animal model will utilize the progressive ratio schedule of cocaine self- administration, with a concurrent, sequential, or parallel second reinforcer (a food- or water--maintained schedule) to assess the general condition of the rats. It is anticipated that eight to twelve compounds will be studied each year in each of the several paradigms of the basic model that are designed by the contractor. The compounds will be assigned by the Project Officer.