STUDIES OF 1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE

以下慢性毒性/致癌性和 1，2-二氢-2，2，4-三氟乙酸的引发/促进研究 三甲基喹啉（TMQ）的反应。 1.在F344大鼠和B6 C3 F1小鼠中进行的104周皮肤涂料研究， 涉及3个剂量水平加对照，包括动物组 每周收到5或3份申请。完整组织病理学检查 评价是要做的。 2.使用雄性F344大鼠进行的26周启动/促进研究， 进行为期72周的研究。这项为期26周的研究涉及 7个处理组，确定 GGT病灶。 组织学仅限于肝脏。 任择 72-为期一周的研究涉及7个治疗组，并进行中期处死 在26周和52周。 各组将治疗72周，或将 治疗长达52周，停止治疗， 直至研究结束（72周）。 所有小组将有 进行了有限的组织病理学和GGT评价。 3.在雌性Sencar小鼠中进行的52周启动/促进研究。 一 初步剂量探索研究将进行21天。 的 52-为期一周的研究涉及13个治疗组，使用3个剂量水平的 TMQ。 组织学仅限于皮肤和肝脏。

The following chronic toxicity/carcinogenicity and initiation/promotion studies of 1,2-Dihydro-2,2,4- trimethylquinoline(TMQ) are to be conducted. 1. A 104-week skin paint study in F344 rats and B6C3F1 mice which involves 3 dose levels plus controls, including groups of animals receiving 5 or 3 applications/week. Complete histopathologic evaluation is to be done. 2. A 26-week initiation/promotion study using male F344 rats with the option to conduct a 72-week study. The 26-week study involves 7 treatment groups with a determination of the number and size of GGT foci. Histopathology is limited to the liver. The optional 72-week study involves 7 treatment groups with interim sacrifices at 26 and 52 weeks. Groups will be treated for 72 weeks or will be treated for up to 52 weeks, treatment withdrawn and the animals held until the end of the study (72 weeks). All groups will have limited histopathologic and GGT evaluations performed. 3. A 52-week initiation/promotion study in female Sencar mice. A preliminary dose finding study is to be conducted for 21 days. The 52-week study involves 13 treatment groups using 3 dose levels of TMQ. Histopathology is limited to the skin and liver.