Novel green scalable chemical peptide synthesis and enzyme immobilization

该项目旨在解决为多肽的化学生产开发绿色工艺的关键问题，包括工业规模的生产。它将使用我们的合作伙伴SpheriTech Ltd发明的独特的生物相容性固体载体以及其他试剂，使合成可以在水中进行，而不是在有毒的有机溶剂中进行。该项目的预期成果包括通过固相合成和固定酶介导的连接在多肽及其类似物的高效环境友好组装方面建立国际伙伴关系。明显的好处将是第一个新颖的、基于水的、可扩展的多肽作为生物探针和潜在的治疗剂的绿色合成。

The Project aims to address the critical issue of developing green processes for the chemical production of peptides including on an industrial scale. It will use unique, biocompatible solid supports that have been invented by our partner SpheriTech Ltd together with other reagents to allow synthesis to be conducted in water rather than toxic organic solvents. Expected outcomes of the Project include an international partnership in highly efficient environmentally-friendly assembly of peptides and of their analogues by both solid phase synthesis and immobilized enzyme-mediated ligation. The clear benefit will be the first novel, water-based, scalable green synthesis of peptides as biological probes and potential therapeutic agents.