QUANTITATIVE ANALYSIS OF OPTIC DISC/OCULAR HYPERTENSION

本申请描述了一项针对高眼压的辅助研究 治疗研究（OHTS），一项多中心临床试验，由 国家眼科研究所，以确定共聚焦的有效性 扫描激光检眼镜，客观地评估视盘， 高眼压患者。 具体目标：1。评价共焦扫描激光成像的使用 青光眼视神经损害及眼部改变的检测技术 高血压患者。2.为了研究定量的时间 视神经地形图与可测视野的关系 损失3.评价治疗对视神经地形图的影响。4. 比较非裔美国人和白色人的视盘地形参数 高眼压患者。 方法：21家OHTS研究中心中的6家将参与本研究。 辅助研究;至少400例高眼压患者将 包括.共聚焦激光扫描检眼镜将用于测量 随机化访视时的视盘和视乳头周围地形图，以及 此后在研究期间每年一次。 共焦扫描 激光检眼镜阅读中心将在广州大学成立 加州圣地亚哥处理和分析图像。确保 这项辅助研究不会影响招募，保留， 初步试验的实施或初步结果的评估， 阅读中心将对所有受试者的身份和治疗状态设盲 患者将对这些数据进行定量评价，以证明 与其他结构和构造的损伤和变化进行了比较， 在OHTS中获得的青光眼视神经病变的功能测量。 这项研究将评估这些进展是否在眼底成像 技术可以提高我们检测和监控的精度， 青光眼性视神经病变

This application describes an ancillary study to the Ocular Hypertension Treatment Study (OHTS), a multicenter clinical trial sponsored by the National Eye Institute, to determine the effectiveness of confocal scanning laser ophthalmoscopy to objectively evaluate the optic disc in ocular hypertensive patients. Specific Aims: 1. To evaluate the use of confocal scanning laser imaging techniques to detect glaucomatous optic nerve damage and change in ocular hypertensive patients. 2. To investigate the quantitative temporal relationship between optic nerve topography and measurable visual field loss. 3. To evaluate the effect of treatment on optic nerve topography. 4. To compare topographic optic disc parameters in African-American and white ocular hypertensive patients. Methods: Six of the 21 OHTS study centers will participate in this ancillary study; at least 400 ocular hypertensive patients will be included. Confocal laser scanning ophthalmoscopy will be used to measure optic disc and peripapillary topography at the randomization visit, and annually thereafter for the duration of the study. A Confocal Scanning Laser Ophthalmoscopy Reading Center will be established at University of California, San Diego to process and analyze the images. To ensure that this ancillary study will not jeopardize recruitment, retention, implementation of the primary trial or assessment of the primary findings, the reading center will be masked to identity and treatment status of all patients. These data will be evaluated quantitatively for evidence of glaucomatous damage and change, and compared with other structural and functional measures of glaucomatous optic neuropathy obtained in the OHTS. This study will evaluate whether these advances in fundus imaging technology can improve the precision with which we can detect and monitor glaucomatous optic neuropathy.