PREVALENCE OF PREMENSTRUAL DYSPHORIC DISORDER

描述（改编自申请人的摘要）： 经前焦虑障碍（PMDD）作为DSM-IV的诊断类别 一直在激烈争论，争论的焦点是， 实证支持其存在。 该研究旨在提供 是否存在PMDD并具有基于DSM-IV的诊断有效性的证据 研究标准。 其他目的是确定1） PMDD与其他精神疾病同时发生，2）经前 其他轴1精神疾病加重，和3）既往精神疾病 目前诊断为经前抑郁症和未诊断为经前抑郁症的女性中的疾病。 2600名年龄在13岁至55岁之间的妇女将被 通过概率抽样选择并跟踪两个月经周期。 一半受试者将来自圣路易斯MSA，另一半来自 芝加哥海事局。 城市和农村的子样本将分别从这两个地区抽取。 地理区域。 将要求受试者填写每日症状 问卷调查，并提供研究期间的每日尿液样本。 后者将用于确定周期的阶段。 关于 症状问卷将被喜欢到周期的阶段， 可以比较经后和经前期的严重程度， 第一个DSM-IV研究标准。 症状严重程度为 采用绝对严重度法和Trigg趋势法进行分析 分析. PMDD的其他DSM-IV研究标准将通过以下方式解决： 跟踪受试者两个周期，并通过以下措施：1）干扰 功能和2）精神病诊断。 干扰功能 将每天测量。 精神科面谈将在 研究开始时受试者的家（以获得当前和 终身诊断）和此后每月（评估 相关精神疾病症状的经前变化）。 Rasch分析将用于确认PMDD的定义， 建立经前抑郁症妇女的档案。

DESCRIPTION (Adapted from the Applicant's Abstract): The inclusion of Premenstrual Dysphoric Disorder (PMDD) as a diagnostic category of DSM-IV has been hotly debated with controversy centering on the continued lack of empirical support for its existence. The proposed research seeks to provide evidence on whether PMDD exists and has diagnostic validity based on DSM-IV research criteria. Additional aims are to determine the prevalence of 1) PMDD co-occurring with other psychiatric disorders, 2) premenstrual exacerbations of other Axis 1 psychiatric disorders, and 3) past psychiatric disorders among women with and without a current diagnosis of PMDD. Two thousand six hundred women between the ages of 13 and 55 years will be selected by probability sampling and followed for two menstrual cycles. Half of the subjects will be drawn from the St. Louis MSA and half from the Chicago MSA. Urban and rural subsamples will be drawn from each of the two geographic areas. Subjects will be asked to complete daily symptom questionnaires and provide daily urine specimens for the period of study. The latter will be used to establish phase of cycle. Responses on the symptom questionnaire will be liked to phase of cycle so that symptom severity during the postmenstrual and premenstrual phases can be compared, as per the first DSM-IV research criteria. Symptom severity will be analyzed using the absolute severity method and the Trigg method of trend analysis. Other DSM-IV research criteria for PMDD will be addressed by following subjects for two cycles and via measures of 1) interference with functioning and 2) psychiatric diagnoses. Interference with functioning will be measured daily. Psychiatric interviews will be conducted in subjects' homes at the beginning of the study (to obtain current and lifetime diagnoses) and on a monthly basis thereafter (to assess premenstrual change in the symptoms of relevant psychiatric disorders). Rasch analysis will be used to confirm the definition of PMDD and to establish profiles of women with PMDD.