TYROSINE PHOSPHORYLATION & CELL SIGNALING

蛋白质在酪氨酰残基上的磷酸化现在被认为是 是控制这种基本细胞的基本要素 生长、增殖、分化、细胞骨架等过程 功能和细胞周期。我们目前见证了一个杰出的 在确定结构、调节和功能方面取得进展的时期 蛋白酪氨酸激酶(PTKs)和蛋白酪氨酸磷酸酶 (PTPs)，它的协调作用调节细胞水平 磷酸酪氨酸。关于“酪氨酸”的第三次会议的目标 磷酸化和细胞信号“是提供一种形式，在这种形式下， 将整合对PTK和PTP的研究，以帮助参与者了解如何 他们的研究结果有助于整体的“大局”。我们将组织 以生理过程和细胞功能为基础的会议， 而不是围绕特定类别的酶，以便尝试和 提供生物学背景。 除了雷·埃里克森和萨拉的主旨演讲 所有演讲者将从提交的摘要中选出。这 将使重点放在鼓励研究生、博士后 和年轻的独立调查人员来介绍会谈。它也应该 便于展示最新和最热门的结果。我们 预计将有300-350人出席，其中将作口头报告 此外，还将有约160人将作宣传画。这些资金 本提案中要求的将使更多的年轻调查人员能够 参与，特别是那些还没有独立资金的人。 我们希望在本次会议上整合关于PTK和PTP的研究， 强调这些酶的生物学作用，将产生 在整个领域具有凝聚力和沟通能力。

The phosphorylation of proteins on tyrosyl residues is now recognized to be an essential element in the control of such fundamental cellular processes as growth and proliferation, differentiation, cytoskeletaI function and the cell cycle. We are currently witnessing an outstanding period of progress in characterizing the structure, regulation and function of both protein tyrosine kinases (PTKs) and protein tyrosine phosphatases (PTPs), the coordinated action of which governs the levels of cellular phosphotyrosine. The objective of this Third Meeting on "Tyrosine Phosphorylation and Cellular Signaling" is to provide a format in which the study of PTKs and PTPs will be integrated to help participants see how their results contribute to the overall "big picture." We will organize the sessions based around physiological processes and cellular functions, rather than around particular categories of enzymes, so as to try and provide a biological context. With the exception of the Keynote Addresses by Ray Erikson and Sara Courtneidge, all speakers will be selected from submitted abstracts. This will allow emphasis to be placed on encouraging graduate students, postdocs and young independent investigators to present the talks. It also should facilitate the presentation of the most recent and "hottest" results. We anticipate an attendance of 300-350 of which 64 will give oral presentations and approximately 160 will present posters. The funds requested in this proposal will enable more young investigators to participate, especially those who do not yet have independent funding. We hope that the integration of research on PTKs and PTPs at this meeting, placing emphasis on the biological roles of these enzymes, will engender a sense of cohesiveness and communication across the field.