CAFFEINE EFFECTS ON STRESS REACTIVITY

描述：研究者研究的长期目标 该项目旨在研究咖啡因和压力之间的关系 反应性，并确定其对健康和疾病的影响。 这项拟议中的研究旨在调查咖啡因对 心血管和神经内分泌应激反应 环境 动态血压和心率以及 将在正常期间收集儿茶酚胺和皮质醇排泄 工作日的活动，在晚上，并通宵测量 生理应激反应的大小。每日咖啡因剂量将是 在交叉设计中在受试者内进行实验操作， 确定更高的每日咖啡因剂量是否会增加 生理应激反应和更大的主观体验 喝咖啡的男性和女性在工作日的压力。 比较工作日和晚上的措施将确定是否咖啡因 在一天的活动之后，抑制在家的“放松”。 的 研究人员还将研究两组可能有更大风险的人， 咖啡因的影响：使用避孕药的妇女， 吸烟者。 在整个样本中，工作压力，愤世嫉俗的敌意， 和家庭压力的测量将作为潜在的调节因素进行研究 咖啡因和压力的相互作用

DESCRIPTION: The long-term objectives of the investigator's research program are to investigate relationships between caffeine and stress reactivity and to determine their implications for health and disease. The proposed study seeks to investigate caffeine's effects on cardiovascular and neuroendocrine stress responses in the natural environment. Ambulatory blood pressure and heart rate as well as catecholamine and cortisol excretion will be collected during normal workday activities, in the evening, and overnight to measure the magnitude of physiological stress responses. Daily caffeine dose will be experimentally manipulated within-subject in a cross-over design to determine whether higher daily caffeine doses produce increased physiological stress responses and greater subjective experience of stress during the workday in men and women who drink coffee. Comparisons of workday and evening measures will determine if caffeine inhibits "unwinding" at home after the day's activities. The investigators will also study two groups who may be at greater risk from the effects of caffeine: women who use birth control pills, and cigarette smokers. In the entire sample, job strain, cynical hostility, and measures of stress at home will be studied as potential moderators of caffeine/stress interactions.