UCI MRRC CENTER FOR MRDD DISORDERS OF PLASTICITY

拟议中的加州大学欧文分校的学术重点 (UCI)，MRRC是神经和行为系统的可塑性作为一种方法 致MRDD。神经可塑性是神经系统在 被基因、经验和疾病改变的。拟议的人力资源中心将 重视与中枢神经系统可塑性相关的基础研究 儿童可塑性障碍的研究进展及临床研究 MRDD。UCI在神经科学界被公认为 并培养神经可塑性的概念。在过去的17年里， UCI也因临床的平行发展而获得认可 精神发育迟滞的研究，被公认为 MRDD的诊断和治疗方案。拟议的人力资源中心将 正式承认这两种方法的汇合点。该中心将 为调查人员提供核心支持，促进新的合作 这将增加研究的广度和范围。 拟议的MRRC的目标将是：(1)促进跨学科 侧重于MRDD的研究；(2)通过 资源核心系统，将a)确保在 信息处理和数据库管理，b)提供全面的 通过以实验室为基础的文化博览会提供神经发育评估支持 技术，以及c)使用分子生物学方法来识别 提高神经可塑性的生物学基础；(3)促进 参与的临床和基础科学家之间的交流，他们的 学生和研究员，更广泛的大学社区，以及公众； (4)对多元文化/多民族方面进行初步探索 (5)促进相关研究中心之间的合作 UCI和其他MRRC在全国范围内的问题。

The intellectual focus of the proposed University of California, Irvine (UCI), MRRC is plasticity of neural and behavioral systems as an approach to MRDD. Neural plasticity is the process by which the nervous system is altered by genes, experience, and disease. The proposed MRRC will emphasize basic research relating to plasticity of central nervous system development and clinical research relating to disordered plasticity in MRDD. UCI is recognized within the neuroscience community for developing and fostering the concept of neural plasticity. Over the past 17 years,. UCI also gained recognition for the parallel development of clinical research in mental retardation, acknowledged by the visibility of the programs in the diagnosis and treatment of MRDD. The proposed MRRC will formally recognize the confluence of these two approaches. The Center will provide core support for the investigators and promote new collaborations that will increase the breadth and scope of the research. The goals of the proposed MRRC will be to: (1) foster interdisciplinary research focused on MRDD; (2) support these research efforts through a system of resource cores that will a) ensure technological support in information processing and database management, b) provide comprehensive neurodevelopment assessment support via culture-fair, laboratory-based techniques, and c) employ molecular biology methodology to identify with greater precision the biological bases of neural plasticity; (3) promote communication among the participating clinical and basic scientists, their students and fellows, the broader university commnunity, and the public; (4) conduct initial explorations of the multicultural/multiethnic aspects of MRDD, and (5) facilitate collaboration among Centers studying related problems at UCI and other MRRCs nationally.