Biodegradable Antibacterial Nanoparticles: The Next Generation of Antibiotics

耐多药微生物如耐甲氧西林金黄色葡萄球菌和铜绿假单胞菌引起的院内感染在医院环境中经常观察到；导致严重的公共卫生问题。最紧迫的问题是，它们正在对目前几乎所有可用的抗生素产生耐药性。纳米医学提供了新的可能性，包括更少的副作用、对人体细胞的损害最小、更低的药物浓度和更长时间的稳定性。然而，尽管纳米颗粒具有巨大的潜力，但其不可生物降解的性质和长期毒性限制了其在临床实践中的应用。因此，聚酯和镁的抗菌可生物降解纳米颗粒是一个有吸引力的提议。LIG Biowise的初步研究已经证明了一种新技术的可行性，该技术可以使用皮秒激光烧蚀产生这些纳米颗粒。

Nosocomial infections caused by multidrug-resistant microorganisms such as MRSA and P.aeruginosa are observed frequently in hospital settings; resulting in serious public health problems. The most pressing concern is that they are becoming resistant to almost all antibiotics available at the present time. Nanomedicine offers new possibilities including fewer side effects, minimal damages to human cells, and lower drug concentrations and stability for a longer period. However, despite this significant potential, the translation ofnanoparticles to clinical practice is limited by their non-biodegradable nature and long-term toxicity. Hence antimicrobial biodegradable nanoparticles of polyesters and magnesium are an attractive proposition. Initial research from LIG Biowise has demonstrated the feasibility of a new technique that can generate these nanoparticles using picosecond laser ablation.