Antibacterial activity of silver nanoparticles towards oral and wound bacteria embedded in biofilms
银纳米粒子对嵌入生物膜中的口腔和伤口细菌的抗菌活性
基本信息
- 批准号:530267-2018
- 负责人:
- 金额:$ 1.82万
- 依托单位:
- 依托单位国家:加拿大
- 项目类别:Engage Grants Program
- 财政年份:2018
- 资助国家:加拿大
- 起止时间:2018-01-01 至 2019-12-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
Part of the difficulty in treating organisms for bacterial infection is that the bacteria are often embedded within**biofilms, which are complex superstructures in which bacterial microcolonies are dispersed in a matrix of**extracellular polymeric substances, lipids, and metabolites. The development of drugs and molecules that can**efficiently be transported across the complex biofilm matrix is essential in order to prepare effect treatments.**Given the complexity of the biofilms and the development of multidrug resistance, non-traditional antibacterial**agents are of emerging interest for the treatment of pathogenic microorganisms. In this context, SK Nano are**producing novel nanomaterials as a cost-effective alternative to the traditional anti-bacterials. The**nanoparticles have numerous projected applications in antibacterial products, which gives them great potential**for commercialization related to wound care, dermatology, veterinary diseases and oral health problems. Using**state-of-the art techniques that are available in our lab (single particle inductively coupled plasma spectroscopy,**SP-ICPMS; dynamic light scattering, DLS; analytical ultracentrifugation, AUC and transmission electron**microscopy, TEM), we will first precisely characterize novel Ag nanomaterials with different sizes, shapes and**surface coatings are being synthesized by SK Nano. In a second step, anti-bacterial properties of AgNPs (three**different sizes, three different forms, three different surface coatings) will be quantified using confocal**scanning laser microscopy (CSLM). Diffusion of the nanoparticles within the bacterial biofilms will be**evaluated by fluorescence correlation spectroscopy. The project will enable us to better understand**structure-function relationships relating the properties of the novel materials with their biological function.**Such information will both further our mechanistic understanding of these products and allow SK Nano to**better design future products with appropriate antibacterial activity.
治疗细菌感染的部分困难在于细菌通常嵌入生物膜中,生物膜是复杂的上层结构,其中细菌微菌落分散在细胞外聚合物质、脂质和代谢物的基质中。为了制备有效的治疗方法,开发能够有效地在复杂的生物膜基质中运输的药物和分子是必不可少的。鉴于生物膜的复杂性和多药耐药的发展,非传统抗菌药物在治疗病原微生物方面正引起人们的兴趣。在这种情况下,SK Nano正在生产新型纳米材料,作为传统抗菌剂的一种具有成本效益的替代品。纳米颗粒在抗菌产品中有许多预计的应用,这使它们在与伤口护理、皮肤病、兽医疾病和口腔健康问题相关的商业化方面具有巨大的潜力。利用我们实验室现有的最先进的技术(单粒子电感耦合等离子体光谱,**SP-ICPMS,动态光散射,DLS,分析超离心,AUC和透射电子显微镜,TEM),我们将首先精确表征SK纳米合成的具有不同尺寸,形状和表面涂层的新型银纳米材料。在第二步,AgNPs(三种不同尺寸,三种不同形式,三种不同表面涂层)的抗菌性能将使用共聚焦扫描激光显微镜(CSLM)进行量化。纳米颗粒在细菌生物膜内的扩散将通过荧光相关光谱进行评估。该项目将使我们能够更好地理解新型材料的特性与其生物学功能之间的结构-功能关系。这些信息将进一步加深我们对这些产品的机理理解,并允许SK Nano **更好地设计具有适当抗菌活性的未来产品。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Wilkinson, Kevin其他文献
Determination of diffusion coefficients of nanoparticles and humic substances using scanning stripping chronopotentiometry (SSCP)
- DOI:
10.1016/j.colsurfa.2006.08.054 - 发表时间:
2007-03-01 - 期刊:
- 影响因子:5.2
- 作者:
Pinheiro, Jose P.;Domingos, Rute;Wilkinson, Kevin - 通讯作者:
Wilkinson, Kevin
Improved fish and crustacean passage in tidal creeks following floodgate remediation
- DOI:
10.1111/j.1365-2664.2011.02101.x - 发表时间:
2012-02-01 - 期刊:
- 影响因子:5.7
- 作者:
Boys, Craig A.;Kroon, Frederieke J.;Wilkinson, Kevin - 通讯作者:
Wilkinson, Kevin
Wilkinson, Kevin的其他文献
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{{ truncateString('Wilkinson, Kevin', 18)}}的其他基金
Environmental fate of data poor inorganic contaminants- Developing novel tools and a better fundamental understanding
数据贫乏的无机污染物的环境命运——开发新工具和更好的基本理解
- 批准号:
RGPIN-2019-05983 - 财政年份:2022
- 资助金额:
$ 1.82万 - 项目类别:
Discovery Grants Program - Individual
Novel silver nanoparticles as antibacterial agents
作为抗菌剂的新型银纳米颗粒
- 批准号:
521908-2018 - 财政年份:2021
- 资助金额:
$ 1.82万 - 项目类别:
Collaborative Research and Development Grants
Environmental fate of data poor inorganic contaminants- Developing novel tools and a better fundamental understanding
数据贫乏的无机污染物的环境命运——开发新工具和更好的基本理解
- 批准号:
RGPIN-2019-05983 - 财政年份:2021
- 资助金额:
$ 1.82万 - 项目类别:
Discovery Grants Program - Individual
Towards a better understanding of contaminant bioavailability- urgent replacement of photosynthetic incubators
更好地了解污染物的生物利用度——紧急更换光合培养箱
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RTI-2022-00353 - 财政年份:2021
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$ 1.82万 - 项目类别:
Research Tools and Instruments
Advanced Technological Training network on the risk and remediation of Pollution in URban Environments (PURE CREATE)
关于城市环境污染风险和修复的高级技术培训网络(PURE CREATE)
- 批准号:
528220-2019 - 财政年份:2021
- 资助金额:
$ 1.82万 - 项目类别:
Collaborative Research and Training Experience
Advanced Technological Training network on the risk and remediation of Pollution in URban Environments (PURE CREATE)
关于城市环境污染风险和修复的高级技术培训网络(PURE CREATE)
- 批准号:
528220-2019 - 财政年份:2020
- 资助金额:
$ 1.82万 - 项目类别:
Collaborative Research and Training Experience
Novel silver nanoparticles as antibacterial agents
作为抗菌剂的新型银纳米颗粒
- 批准号:
521908-2018 - 财政年份:2020
- 资助金额:
$ 1.82万 - 项目类别:
Collaborative Research and Development Grants
Environmental fate of data poor inorganic contaminants- Developing novel tools and a better fundamental understanding
数据贫乏的无机污染物的环境命运——开发新工具和更好的基本理解
- 批准号:
RGPIN-2019-05983 - 财政年份:2020
- 资助金额:
$ 1.82万 - 项目类别:
Discovery Grants Program - Individual
Development of analytical procedures for the determination of engineered nanomaterials in food by Single-Particle ICP-MS
开发单颗粒 ICP-MS 测定食品中工程纳米材料的分析程序
- 批准号:
542975-2019 - 财政年份:2020
- 资助金额:
$ 1.82万 - 项目类别:
Collaborative Research and Development Grants
Novel silver nanoparticles as antibacterial agents
作为抗菌剂的新型银纳米颗粒
- 批准号:
521908-2018 - 财政年份:2019
- 资助金额:
$ 1.82万 - 项目类别:
Collaborative Research and Development Grants
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