ACCESSORY CELLS AND BONE PRECURSOR CELL DEVELOPMENT

骨质疏松症和其他退行性骨骼疾病有严重的 对老年人健康的影响。这个实验室有 新近蝇在纯化后表现出一些与年龄相关的变化 从人骨髓中获得的人骨前体细胞。基于 假设这种细胞群体中与年龄相关的变化是 与与骨骼的专属相互作用中的变化相关- 辅助细胞群体，本项目将调查：a) 骨辅助细胞群体的表型；b)功能性 这些细胞的意义；以及c)与年龄相关的变化 在骨辅助细胞群体中的位置。这项研究将提供 更好地理解植物生长调控机制 成骨细胞谱系，并将为改善 退行性骨病的未来治疗。

Osteoporosis and other degenerative bone diseases have a serious impact on the health of elderly individuals. This laboratory has recenfly characterized a number of age-related changes in purified human bone precursor cells obtained from human bone marrow. Based on the hypothesis that age-related changes in this cell population are associated with changes in an obligate interaction with a bone- accessory cell population, this project will investigate: a) the phenotype of the bone-accessory cell population; b) the functional significance of these cells; and c) the age-related changes that take place in the bone-accessory cell population. This study will provide a better understanding of the mechanism of growth regulation in the osteoblast lineage, and will provide a foundation for improvement of future treatments for degenerative bone diseases.