Molecular determinants of inflammatory caspase activity upon inflammasomes

大多数生命的基本过程都依赖于细胞功能的及时、受调节的执行。先天免疫系统的时间和调控都是至关重要的，它能迅速发现入侵的微生物，并诱导出有节制的、及时的抗微生物反应来清除感染。该项目旨在通过表征非典型炎性体及时和受控的免疫系统激活和免疫细胞死亡的机制来解决关键的知识空白。我们目前还不了解一些免疫途径是如何开启或关闭的。该项目将对哺乳动物炎性体、炎症和抗微生物反应的机制产生根本性的见解。

Most processes fundamental to life rely on the timely, and regulated, execution of cellular functions. The innate immune system, in which both timing and regulation is paramount, rapidly detects invading microbes and induces a measured and timely antimicrobial response to clear infection. This project aims to address a key knowledge gap by characterising a mechanism for timely and controlled immune system activation and immune cell death via the non-canonical inflammasome. We do not currently understand how some immune pathways are turned on or off. This project will yield fundamental insight into mechanisms of mammalian inflammasome, inflammation and anti-microbial responses.