IBEX Dynamic X-ray imaging of reduced iodine contrast agents in angiography procedures

IBEX创新公司在之前的原型开发项目中成功展示了其多吸收板（MAP） x射线探测器技术的材料分类能力。使用集成到标准医用平板探测器（FPD）的MAP技术识别医学图像中的材料的能力提供了显著的优势，包括在标准数字放射照相（DR）设备上测量骨矿物质密度（BMD）的能力。血管造影系统使用放射性不透明造影剂（通常是碘溶液）的x射线吸收造影剂来显示体内的血管和器官，并用于协助诊断和治疗心脏病（冠状动脉造影）或脑部疾病（神经血管造影）。已知在约2%的血管造影手术中，基于碘的造影剂通过造影剂肾病（CIN）损害肾功能，在高危患者中增加到20-30%。该项目旨在证明IBEX材料分类方法可以通过材料类型而不是x射线阻断特性来识别造影剂。这提供了成像低浓度碘而不损失造影剂的潜力，或使用新型无害造影剂，可以通过其材料与身体结构的差异来区分。该项目还将证明IBEX材料分类技术可以实时生成运动造影剂的图像。最后，该项目将寻求在动态图像中证明骨和组织的抑制作为数字减影血管造影（DSA）方法的替代方法。

IBEX Innovations has successfully demonstrated, in a previous Development of Prototype project, the materials classification capability of its Multi-Absorption Plate (MAP) X-ray detector technology. The ability to identify materials in a medical image using the MAP technology integrated to a standard medical flat panel detector (FPD) offers significant benefits, including the ability to measure bone mineral density (BMD) on standard Digital Radiography (DR) equipment.Angiography systems use X-ray absorption contrast of a radio-opaque contrast agent, usually an iodine solution, to visualise blood vessels and organs in the body and are used to assist in diagnosis and treatment of heart conditions (Coronary Angiography) or brain conditions (Neuro-vascular Angiography).Iodine-based contrast agents are known to impair renal function through Contrast Induced Nephropathy (CIN) in around 2% of angiography procedures, increasing to 20-30% in high risk patients. This project seeks to demonstrate that the IBEX materials classification methods can identify contrast agents by their material type rather than their X-ray blockingcharacteristics. This offers the potential to image much lower concentrations of iodine with no loss in contrast, or to use new types of non-harmful contrast media that can be distinguished by virtue of their material differences from the structures of the body. The project will also demonstrate that the IBEX materials classification technology can generate images of moving contrast agent in in real time. Finally, the project will seek to demonstrate suppression of bone and tissue in the dynamic image as an alternative approach to digital subtraction angiography (DSA) methods.