PEDIATRIC PHASE I TRIAL AND PHARMACOKINETIC STUDY OF LGC1057

类维生素A如顺式维甲酸（RA）具有广谱活性 在正常组织中引起生长抑制和分化， 一系列儿科恶性肿瘤的体外实验 在患者中，全反式- 已使用视黄酸（ATRA）和13-顺-视黄酸，尽管 具有不同的抗肿瘤功效谱。 一些理论 考虑因素和一些实验室数据表明，9-顺式-RA可能更多 作为抗肿瘤剂比其它类维生素A更有效。 这项建议 使用标准的I期设计和药代动力学。

Retinoids such as cis-retinoic acid (RA) have a broad spectrum of activity in causing growth inhibition and differentiation in normal tissue and in a number of pediatric malignancies in vitro. In patients, both all-trans- retinoic acid (ATRA) and 13-cis-retinoic acid have been used, although with a different spectrum of anti-tumor efficacy. Some theoretic considerations and some laboratory data suggest that 9-cis-RA may be more potent than other of the retinoids as an anti-tumor agent. This proposal uses a standard phase I design and pharmacokinetics.