ALUMINUM IN ALZHEIMERS DISEASE

铝在阿尔茨海默病病因中的作用仍然存在 由于现场报道的结果相互矛盾，因此存在争议。 与疾病有关的固定样本和染色样本的测量 斑块和缠结可以识别被批评为可能 元素再分配和污染。即使有了一个 夹心切片技术，在这种技术中，斑块不固定，不染色 切片可以从它们的位置定位在两个相邻的染色区域 各节，关于结构的不确定性仍然存在，因此，也关于 有意义的铝浓度。一种改良的硫代黄素染色效果观察 阿尔茨海默病脑冰冻切片中元素分布的研究 使用能量色散X射线光谱学对组织进行了检查 (EDS)分析染色前后斑块成分。确实是 发现，尽管染色改变了整体成分，但 铝和其他元素，如硅和铁，在 染色。基于这一发现，铝与斑块的关系 正在对硫代黄素染色切片中的结构进行研究。

The role of aluminum in the etiology of Alzheimer's disease remains controversial because of the contradictory results reported in the field. Measurements on fixed and stained samples in which disease-related plaques and tangles can be identified are criticized for possible elemental redistribution and contamination. Even with a sandwich-section technique, in which plaques in an unfixed, unstained section can be located from their position in two adjacent stained sections, uncertainty remains about structure and, therefore, also about meaningful Al concentrations. The effect of a modified thioflavin stain on elemental distributions in cryosections of Alzheimer's disease brain tissue has been examined, using energy- dispersive X-ray spectroscopy (EDS) to analyze plaque composition before and after staining. It was found that, although staining alters the overall composition, peaks for Al and other elements such as Si and Fe are relatively unchanged by staining. Based on this finding, the relationship of Al to plaque structure is being investigated in thioflavin-stained sections.