COMPONENTS OF WORKING MEMORY DEFICIT IN SCHIOPHRENIA

描述（改编自申请人的摘要）：本研究的主要目标 该项目旨在分析工作记忆的神经认知成分 精神分裂症的缺陷 这三项拟议研究的目的是 指定前额叶工作记忆系统的参数， 描述其与以下症状表达的可能联系： 精神分裂症 研究人员的总体假设是， 通过前额叶工作记忆系统来调节行为， 精神分裂症的主要特征 越来越多的证据支持这一观点 但工作记忆在临床症状中的作用尚不清楚，因为 额叶的功能异质性， 工作记忆系统和症状的扩散定义。 的作用 背外侧前额叶和腹侧/眶额系统 精神分裂症将通过一系列特定的实验进行探索 旨在评估多重工作的分离和整合， 记忆系统空间工作记忆是由神经回路介导的 包括背外侧前额叶皮层，而视觉（非空间） 和嗅觉工作记忆系统的完整性有关， 腹侧/眶额系统 有3项研究，包括3项 每个实验 研究1的重点是检查空间，视觉 （非空间）和嗅觉工作记忆系统分别在 精神分裂症患者，以确定哪些系统是 与波动性症状无关的持续受损， 系统与症状有关。 精神分裂症的年轻兄弟姐妹 将对患者进行测试，看看他们是否表现出类似的缺陷模式。 研究2关注的是如何确定这些解剖学和 心理上可分离的工作记忆系统是分离的， 协调或抑制，以指导控制机制的行动（ “中央执行”）。 在研究3中，连接的完整性 将检查眶额和背外侧前额叶系统之间的关系 通过考察情绪、唤醒和奖赏对工作记忆的作用。 最终，工作记忆的所有组成部分和 额叶系统必须整合在具有完整人格的有机体中 和自我调节的行为。 理解认知缺陷和精神分裂症症状的关键 可以在这些分子的解离和整合模式中找到 多个系统，以响应特定的任务需求。 总之，这 该项目将使调查人员能够进一步确定和阐明 精神分裂症的神经认知成分，从而有助于我们 理解大脑皮层功能之间复杂的相互作用， 男性和女性的认知缺陷和临床综合征 精神分裂症

DESCRIPTION (Adapted from applicant's abstract): The major goal of this project is to analyze the neurocognitive components of working memory deficits in schizophrenia. The three proposed studies are designed to specify parameters of the prefrontal working memory systems and to characterize their possible links to the expression of the symptoms of schizophrenia. The investigator's global hypothesis is that an inability to regulate behavior by prefrontal working memory systems may demarcate cardinal features of schizophrenia. Growing evidence supports this view but the role of working memory in clinical symptoms is unclear, because of the functional heterogeneity of the frontal lobes, multiplicIty of the working memory systems and diffuse definitions of symptoms. The roles of the dorsolateral prefrontal and ventral/orbitofrontal systems in schizophrenia will be probed, using a series of specific experiments designed to assess dissociation and integration of the multiple working memory systems. Spatial working memory is mediated by a neural circuitry including the dorsolateral prefrontal cortex, whereas visual (nonspatial) and olfactory working memory systems are associated with the integrity of the ventral/orbitofrontal system. There are 3 studies, consisting of 3 experiments each. Study 1 is focused on examining spatial, visual (nonspatial) and olfactory working memory systems separately in schizophrenia patients in order to determine which systems are consistently impaired independent of fluctuating symptoms versus which systems are linked to the symptoms. Young siblings of schizophrenia patients will be tested to see if they show similar patterns of deficit. Study 2 is concerned with determining how these anatomically and psychologically separable working memory systems are dissociated, coordinated or inhibited to guide action by a control mechanism (the "central executive"). In Study 3, the integrity of the connections between orbitofrontal and dorsolateral prefrontal systems will be examined by inspecting the roles of affect, arousal and reward on working memory. Ultimately, all the components of working memory and subdivisions of frontal systems must be integrated in an organism with intact personality and self-regulating behaviors. The key to understanding cognitive deficits and symptoms of schizophrenia may be found in the patterns of dissociation and integration of these multiple systems, in response to specific task demands. In summary, this project will enable the investigator to further identity and elucidate neurocognitive components of schizophrenia and thus contribute towards our understanding of the complex interplay between cortical functions, cognitive deficits and clinical syndromes in men and women with schizophrenia.