COMPONENTS OF WORKING MEMORY DEFICIT IN SCHIZOPHRENIA

描述(改编自申请人的摘要)：本报告的主要目标 该项目旨在分析工作记忆的神经认知成分 精神分裂症的缺陷。这三项拟议的研究旨在 指定前额叶工作记忆系统的参数并 描述它们可能与以下症状的表现有关的联系 精神分裂症。研究人员的全球假设是，一种无能 通过前额叶工作记忆系统来调节行为可能会区分 精神分裂症的基本特征。越来越多的证据支持这一观点 但工作记忆在临床症状中的作用尚不清楚，因为 额叶功能的异质性，额叶的多样性 工作记忆系统和症状的扩散定义。的角色 前额背外侧系统和腹侧/眶前系统 将通过一系列具体的实验来探索精神分裂症 旨在评估多项工作的分离和整合 记忆系统。空间工作记忆是由神经回路调节的 包括背外侧前额叶皮质，而视觉(非空间) 嗅觉工作记忆系统与 腹侧/眶前系统。共有3项研究，由3项研究组成 每个人都做实验。研究1的重点是检查空间、视觉 (非空间)和嗅觉工作记忆系统分别位于 精神分裂症患者，以确定哪些系统 持续受损，不受波动症状的影响 系统与症状有关。精神分裂症的年幼兄弟姐妹 患者将接受测试，看看他们是否表现出类似的缺陷模式。 研究2关注的是确定这些解剖学上和 心理上可分离的工作记忆系统是分离的， 协调或禁止通过控制机制(控制机构)引导行动 “中央行政人员”)。在研究3中，连接的完整性 将检查眼眶额叶和背外侧前额叶系统之间的关系 通过考察情绪、唤醒和奖励在工作记忆中的作用。 归根结底，工作记忆的所有组成部分和 额叶系统必须整合在一个具有完整人格的有机体中 和自我调节行为。 理解精神分裂症认知缺陷和症状的关键 可以在它们的解离和整合的模式中找到 多个系统，以响应特定的任务需求。总而言之，这是 该项目将使调查员能够进一步确认和澄清 精神分裂症的神经认知成分，从而有助于我们的 理解皮质功能之间复杂的相互作用， 男性和女性精神分裂症患者的认知障碍和临床症状 精神分裂症。

DESCRIPTION (Adapted from applicant's abstract): The major goal of this project is to analyze the neurocognitive components of working memory deficits in schizophrenia. The three proposed studies are designed to specify parameters of the prefrontal working memory systems and to characterize their possible links to the expression of the symptoms of schizophrenia. The investigator's global hypothesis is that an inability to regulate behavior by prefrontal working memory systems may demarcate cardinal features of schizophrenia. Growing evidence supports this view but the role of working memory in clinical symptoms is unclear, because of the functional heterogeneity of the frontal lobes, multiplicIty of the working memory systems and diffuse definitions of symptoms. The roles of the dorsolateral prefrontal and ventral/orbitofrontal systems in schizophrenia will be probed, using a series of specific experiments designed to assess dissociation and integration of the multiple working memory systems. Spatial working memory is mediated by a neural circuitry including the dorsolateral prefrontal cortex, whereas visual (nonspatial) and olfactory working memory systems are associated with the integrity of the ventral/orbitofrontal system. There are 3 studies, consisting of 3 experiments each. Study 1 is focused on examining spatial, visual (nonspatial) and olfactory working memory systems separately in schizophrenia patients in order to determine which systems are consistently impaired independent of fluctuating symptoms versus which systems are linked to the symptoms. Young siblings of schizophrenia patients will be tested to see if they show similar patterns of deficit. Study 2 is concerned with determining how these anatomically and psychologically separable working memory systems are dissociated, coordinated or inhibited to guide action by a control mechanism (the "central executive"). In Study 3, the integrity of the connections between orbitofrontal and dorsolateral prefrontal systems will be examined by inspecting the roles of affect, arousal and reward on working memory. Ultimately, all the components of working memory and subdivisions of frontal systems must be integrated in an organism with intact personality and self-regulating behaviors. The key to understanding cognitive deficits and symptoms of schizophrenia may be found in the patterns of dissociation and integration of these multiple systems, in response to specific task demands. In summary, this project will enable the investigator to further identity and elucidate neurocognitive components of schizophrenia and thus contribute towards our understanding of the complex interplay between cortical functions, cognitive deficits and clinical syndromes in men and women with schizophrenia.