MOLECULAR ANALYSIS OF CYTOKINESIS IN DICTYOSTELIUM

描述：这位调查员为 对细胞质分裂的理解。负责完成以下任务的机制 胞质分裂仍不明确。在本支助期内， 申请者进行了基因筛查，以确定与 胞质分裂。鉴定出了两个基因。第一个是RACE，一个小的GTP酶 这似乎是一种重要的信号分子，需要 胞质分裂。第二个基因名为lvsa，与小鼠的米色有同源性。 和人类的FAN蛋白，也是细胞质分裂所必需的。这个 当前的应用程序建立在这些发现的基础上，旨在剖析角色 这两个基因在胞质分裂中起作用。提出了三个具体目标：(1) 确定种族在胞质分裂中的作用，(2)确定其他什么 分子与RACE相互作用，以及(3)确定LVSA在 胞质分裂。

DESCRIPTION: This investigator has made significant contributions to the understanding of cytokinesis. The mechanisms responsible for completing cytokinesis remain poorly defined. During the current period of support the applicant performed a genetic screen to identify novel proteins involved in cytokinesis. Two genes were identified. The first is racE, a small GTPase that appears to be an important signalling molecule required for cytokinesis. The second gene, called lvsA, has homology to the murine beige and the human FAN proteins, and is also required for cytokinesis. The current application builds on these findings with aims to dissect the role these two genes play in cytokinesis. Three specific aims are proposed: (1) to determine the role racE plays in cytokinesis, (2) to determine what other molecules interact with racE, and (3) to determine the role lvsA plays in cytokinesis.