XII INTERNATIONAL POXVIRUS SYMPOSIUM

痘病毒是一种复杂的DNA病毒， 从宿主细胞中获得遗传和身体上的自主性。感染是 仅限于受感染细胞的细胞质，并且绝大多数 参与病毒基因表达，基因组复制， 和形态发生在192 kb病毒基因组内编码。 此外，委员会认为， 基因组编码大量蛋白质， 并操纵宿主的免疫、炎症和抗病毒反应。 这种不寻常的组合-其中基本生命周期占主导地位 因此可以用基因精确度来研究， 感染与广谱病毒/宿主密切相关 相互作用-使这些病毒有趣和富有成效的系统， 最先进的研究 痘病毒在生物医学中的重要性 牛痘病毒的成功应用说明了这一历史。 一场全球性的疫苗接种运动， 威胁 今天，重组痘病毒被设计成多价的， 用于医疗和兽医目的的疫苗。 的出现 传染性软疣，另一种痘病毒，作为一种主要的机会性 艾滋病患者的感染强调了这些持续的相关性， 病毒对人类疾病的影响。 国际痘病毒研讨会每两年举行一次， 介绍和讨论痘病毒研究的首要论坛。 的 1998年会议是第12届痘病毒研讨会，并应证明， 和以前的会议一样，具有启发性和信息性。 我们希望有 在八次科学会议上进行七十至八十次口头报告， 在另外两次科学会议上作80张海报介绍。 所有 演讲者将从提交摘要的人中选出。 这 这一方法将有助于介绍最新和 令人兴奋的结果，并应增加年轻人的参与 研究人员、博士后研究员和研究生。基于 在过去的会议上，我们预计大约有175名科学家 将出席。

Poxviruses are complex DNA viruses which exhibit an unusual degree of genetic and physical autonomy from the host cell. Infection is restricted to the cytoplasm of the infected cell, and the vast majority of the proteins involved in viral gene expression, genome replication, and morphogenesis are encoded within the 192 kb viral genome. Moreover, the genome encodes a large repertoire of proteins which intersect with and manipulate the host's immune, inflammatory and anti-viral responses. This unusual combination - in which the basic life cycle is dominated by viral genes and so can be studied with genetic precision, but infection is intimately associated with a broad spectrum of virus/host interactions - makes these viruses intriguing and fruitful systems for state-of-the-art research. The importance of poxviruses in biomedical history is illustrated by the successful use of vaccinia virus in the worldwide vaccination campaign that eradicated smallpox as a human threat. Today, recombinant poxviruses are being designed as multivalent vaccines for both medical and veterinary purposes. The emergence of Molluscum contagiosum, another poxvirus, as a major opportunistic infection of AIDS patients underscores the continuing relevance of these viruses to human disease. The International Poxvirus Symposia are held biannually and are the premier forum for presentation and discussion of poxvirus research. The 1998 meeting is the XIIth Poxvirus Symposium, and should prove as stimulating and informative as previous conferences. We expect to have seventy to eighty oral presentations in eight scientific sessions, and eighty poster presentations in two additional scientific sessions. All presenters will be chosen from those submitting Abstracts. This approach will facilitate the presentation of the most recent and exciting results, and should increase participation by young investigators, post-doctoral fellows and graduate students. Based on previous conferences, we anticipate that approximately 175 scientists will attend.