GORDON CONFERENCE ON MUTAGENESIS, 1998

描述：(改编自《调查员摘要》)申请资金 支持科学家参加第十一届戈登双年展 诱变研究会议将在普利茅斯州立学院举行， 新罕布夏州普利茅斯，1998年6月21日至6月26日。选定的 演讲者是诱变领域的专家，会议将 提供机会讨论他们的最新成果和想法。平等的 重要的是，这次会议将成为广泛互动的论坛。 通过讨论会议和海报在所有出席会议的科学家中 演示文稿。精选海报推荐人(一般为学生及以下 科学家)将有机会介绍他们的研究 以简短的陈述形式讨论结果(五分钟，含间接费用)。 会议通常超额认购，出席人数限制为 135人。参与者是从大学、政府 研究实验室、监管机构、研究机构和 世界各地的工业实验室。1998年会议将延长 对突变发生的机制和策略的理解 被有机体用来调节突变的。简而言之，九次会议 将包括两个关于DNA聚合酶的作用及其编辑活动的内容 在控制复制保真度方面，错配修复在 调节潜在的突变损伤，两个关于处理 内源性DNA损伤，一种是同源重组机制，一种是 非同源重组和双链断裂修复，一个在 DNA交易之间的相互关系及其在 基因组的不稳定性，以及一个特别会议，重点描述 人类基因组中的高危序列。总而言之，大会将 从生化、分子和遗传学的角度研究突变。这个 诱变领域对人类健康的讨论非常重要，因为 自发或来自外部来源的突变似乎会 引发或促进多种人类疾病的发展， 尤其是癌症。

DESCRIPTION: (Adapted from the Investigator's Abstract) Funds are requested to support the travel of scientists to the eleventh bi-annual Gordon Research Conference on Mutagenesis, to be held at Plymouth State College, Plymouth, New Hampshire, from June 21 through June 26, 1998. The selected speakers are experts in the field of mutagenesis and the conference will provide the opportunity to discuss their latest results and ideas. Of equal importance, the meeting will serve as a forum for extensive interactions among all attending scientists through the Discussion Sessions and Poster Presentations. Selected poster presenters (generally students and younger scientists) will be given the opportunity to introduce their research results for discussion in short presentations (five minutes with overheads). The conference is typically oversubscribed with attendance being limited to 135 persons. The participants are selected from universities, government research laboratories, regulatory agencies, research institutes, and industrial laboratories worldwide. The 1998 Conference will extend understanding of the mechanisms by which mutations occur and the strategies employed by organisms to modulate mutagenesis. In brief, the nine sessions will include two on the role of DNA polymerases and their editing activities in controlling replication fidelity, the role of mismatch repair in modulating potentially mutagenic lesions, two on the processing of endogenous DNA damage, one on homologous recombination mechanisms, one on non-homologous recombination and double strand break repair, one on the inter-relationships among DNA transactions and their potential role in genomic instability, and a special session that focuses on delineation of at-risk sequences in the human genome. In summary, the conference will examine mutagenesis from biochemical, molecular and genetic viewpoints. The field of mutagenesis is important to the discussion of human health since mutations, induced spontaneously or from exogenous sources, appear to initiate or facilitate the progression of a multitude of human diseases, particularly cancer.