THROMBOSIS MARKERS OVER TIME IN CARDIOVASCULAR DISEASE

拟议研究的目标是确定是否进行系列评估 心血管疾病(CVD)的新危险因素是一个重要的因素 在老年队列中预测临床心血管事件的工具 心血管健康研究。研究人员有了令人兴奋的新数据 显示止血的生物标记物和 表面健康的受试者炎症与心血管疾病风险增加 65岁以上。这些独特的结果，以及建议的 研究，可能会对心血管疾病的实践产生重大影响 医药。为了定义正常的纵向变化，生物标志物 利息将在相隔三年的两个时间点上计算。一个 以心肌梗死和心脑血管疾病死亡为研究对象的巢式病例对照研究 端点，将完成对它们之间关系的研究 生物标志物的纵向变化与心血管疾病风险。效果修改方式 将对亚临床心血管疾病进行评估。两个时间段的生物标志物水平 将使用点数来确定测量是否接近 心血管事件是心血管事件预测效用的重要决定因素 记号笔。将开发和验证预测模型，以确定 老年人是未来患心血管疾病风险最高的人。候选人是 致力于成为心血管领域的独立研究员 流行病学。加上她出色的医学背景， 完成她的目标，需要流行病学方面的专业知识， 生物统计学、分子生物化学和生理学。候选人 已经开始了这三个领域的培训，正在攻读硕士学位 流行病学，研究老年人止血的流行病学， 并与一个著名的生物化学小组一起参与研究。这个 该奖项的目标是支持知识的扩展和固化 分子流行病学的所有三个关键领域，通过一个重要的 研究项目。这将有助于候选人在 分子心血管流行病学。建议的环境 研究是应聘者需求的理想选择。赞助商，RP Tracy，a 临床化学家，作为分子流行病学家有着重要的作用， 建立了一个以高精度著称的大型实验室 许多流行病学研究中的生物标记物评估。他致力于 应聘者，如申请表中所示。共同发起人--刘慧卿 Kuller在心血管领域做出了广泛的贡献 流行病学，并补充特雷西博士的技能。专业知识 其他顾问是多样化的，与职业生涯很好地匹配 候选人的发展计划，以及研究的目标。 申请人成功的一个关键因素是明确的 机构对她职业发展的承诺。

The goal of the proposed research is to determine if serial assessment of novel risk factors for cardiovascular disease (CVD) is an important tool in prediction of clinical CVD events in an elderly cohort, the Cardiovascular Health Study. The researchers have exciting new data showing strong associations of biomarkers of hemostasis and inflammation with increased CVD risk in apparently healthy subjects over 65. These unique results, along with results of the proposed research, may have a major impact on practice of cardiovascular medicine. To define normal longitudinal change, the biomarkers of interest will be measured at two time points three years apart. A nested case-control study with myocardial infarction and CVD death as endpoints, will be completed to study the relationship between longitudinal change of biomarkers and CVD risk. Effect modification by subclinical CVD will be assessed. Levels of biomarkers at the two time points will be used to determine whether proximity of measurement to CVD event is an important determinant of predictive utility of the markers. Prediction models will be developed and validated to identify older individuals at the highest risk of future CVD. The candidate is committed to becoming an independent investigator in cardiovascular epidemiology. Along with her excellent medical background, to accomplish her goal, expertise is required in epidemiology, biostatistics, and molecular biochemistry and physiology. The candidate has begun training in all three areas, pursuing a masters degree in Epidemiology, studying the epidemiology of hemostasis in the elderly, and participating in research with a notable biochemistry group. The goal of this award is to support expanded knowledge and solidification of all three key areas of molecular epidemiology, through an important research project. This will facilitate success of the candidate in molecular cardiovascular epidemiology. The environment for the proposed research is ideal for the candidate's needs. The sponsor, RP Tracy, a clinical chemist, has a significant role as a molecular epidemiologist, having built a large laboratory with a reputation for high-precision biomarker assessment in many epidemiologic studies. He is committed to the candidate, as demonstrated in the application. The cosponsor, LH Kuller, has contributed broadly to the field of cardiovascular epidemiology, and supplements the skills of Dr. Tracy. The expertise of the other advisors is diverse and well matched to the career development plans of the candidate, and to the aims of the research. A critical factor to the success of the applicant is the unequivocal commitment of the institution to her career development.