GLUCOSE, NEURAL SYSTEMS AND MEMORY

这是一个研究葡萄糖对记忆影响的应用程序 啮齿动物。直接注射到内侧隔、杏仁核和 海马体，第一组实验确定哪种药物对 学习和记忆对额外的直接脑注射 葡萄糖。使用间隔内药物注射和微透析/高效液相色谱法措施 在海马区的乙酰胆碱释放，第二组 实验确定，无论主要目标是什么， 葡萄糖作用，一种预测药物对学习和学习影响的输出 记忆是乙酰胆碱的释放。第三组实验采用了 确定杏仁核对2-脱氧葡萄糖的摄取是否受到抑制 杏仁核内注射吗啡、麝香酚、东莨菪碱、心得安 或AP5，并且仅在前两个实例中恢复(与已知和 预测的行为结果)通过额外的葡萄糖治疗。一个 第四组实验确定是否像葡萄糖和葡萄糖一样 代谢产物可减轻隔内注射吗啡后的记忆损害 打针。这些发现提供了关于 葡萄糖代谢对葡萄糖对学习和学习的影响 记忆。

This is an application to investigate glucose effects on memory in rodents. Using injections directly into the medial septum, amygdala and hippocampus, the first set of experiments determines which drug effects on learning and memory are sensitive to additional direct brain injections of glucose. Using intraseptal drug injections and microdialysis/HPLC measures of acetylcholine release in the hippocampal formation, the second set of experiments determines whether, regardless of the primary target of glucose actions, an output which predicts drug effects on learning and memory is release of acetylcholine. A third set of experiments employs determines whether 2-deoxyglucose uptake in the amygdala is depressed by intra-amygdala injections of morphine, muscimol, scopolamine, propranolol or AP5 and restored only in the first two instances (paralleling known and predicted behavioral results) by additional treatment with glucose. A fourth set of experiments determines whether, like glucose and glucose metabolites can attenuate memory impairments after intraseptal morphine injections. These findings provide initial evidence regarding the contribution of glucose metabolism to glucose effects on learning and memory.