NONINVASIVE PERFUSION MEASUREMENT SYSTEM

本计画开发一套临床监测系统，以量化血流 （灌注）连续地、实时地，使用非侵入式传感器。 灌注量化现在实际上是不可用的，但确保 充分的组织血流被普遍认为是 对许多医疗程序至关重要。 例子包括重建 外科手术、器官移植、血管移植、旁路手术，以及 烧伤和伤口愈合，每一个都依赖于一个可行的脉管系统。 灌注监测系统最终将包括以下阵列： 多个非侵入式表面传感器和平移电子设备， 控制还提供用户界面的个人计算机， 数据收集和管理软件。 本项目第一阶段的目标是 无创灌注传感器的可行性和优化设计。 原型传感器将被制造和评估，热模型 传感器将被配制成从原始功率提取灌注， 时间数据和初步验证研究将表征传感器 灵敏度、响应和准确性。 在第二阶段，非侵入性 传感器设计将被复制到传感器阵列， 组织灌注分布图。 申请将在 许多医疗程序的成功取决于恢复和 维持有活力的组织脉管系统， 缺血组织导致诊断和早期管理选择 的治疗。 建议的商业应用 在50万例肌肉和肌皮瓣重建中， 美国每年也有4,000例肾脏和肝脏移植手术 就像其他手术一样，其成功取决于恢复和维持 有活力的组织脉管系统可以极大地受益于所提出的 将无创地连续量化组织灌注的设备 而且是实时的 当前用于测量组织流量的竞争技术 要么是极其复杂的，只有在 生理研究或过于简单，无法产生有用的信息 在流量水平、变化、量化和空间方面， 分布

This project develop a clinical monitoring system to quantify blood flow (perfusion) continuously, in real-time, using non-invasive senors. Perfusion quantification is now effectively unavailable, yet insuring adequate tissue blood flow is universally acknowledged as being essential to many medical procedures. Examples include reconstructive surgery, organ transplantation, vessel grafting, bypass procedures, and burn and wound healing, each of which depends on a viable vasculature. The perfusion monitoring system will ultimately comprise and array of multiple non-invasive surface sensors and translation electronics under control of a personal computer which also provides the user interface, data collection and management software. This Phase I project addresses the feasibility and optimal design of the non-invasive perfusion sensor. Prototype senors will be fabricated and evaluated, a thermal model of the sensor will be formulated to extract perfusion from raw power versus time data and preliminary validation studies will characterize sensor sensitivity, response and accuracy. In Phase II, the non-invasive sensor design will be replicated to a sensor array designed to provide a map of the tissue perfusion distribution. Applications will be to numerous medical procedures whose success depends on restoring and maintaining a viable tissue vasculature and to the identification of ischemic tissue leading to diagnosis and early options for management of treatment. PROPOSED COMMERCIAL APPLICATION Many of the 500,000 muscle and myocutaneous flap reconstructions, 12,000 kidney and 4,000 liver transplants performed in the US each year as well as other procedures whose success depends on restoring and maintaining a viable tissue vasculature could greatly benefit from this proposed device that will non-invasively quantify tissue perfusion continuously and in real-time. Current competing techniques to measure tissue flow are either extremely complex and performed only in the context of physiologic research or are too simplistic to yield useful information in terms of the flow level, variation, quantification and spatial distribution.