ANTIPLATELET NITRIC OXIDE RELEASING POLYMER COATINGS

血小板激活仍然是体外循环中的一个问题。 研究人员最近表明，合成一氧化氮的释放 化合物(NO-RC)可以并入聚合物基质中 已知的血小板抑制物一氧化氮(NO)的局部释放 粘附力。NO的释放可以通过选择NO-RC来调节 特定的半衰期，通过改变化合物在 聚合物，并通过选择具有所需性能的聚合物 水和NO的扩散。拟议的研究将调查 这项技术在防止血小板的涂料中的应用 与体外循环中使用的材料的粘附性。这个 本申请中描述的化学/聚合物涂层工艺允许 用于逐步、持续和规范地释放极少量的药物 在聚合物/血液界面上的NO，与发生的非常相似 在正常的内皮边界。 一种动物模型将被用来研究一氧化氮释放和血小板之间的关系 与聚合物的粘附性。几个NO-RC将因NO释放而接受调查 和抗血小板效果，同时改变宿主聚合物组成，NO-RC 注意力和血流量。 建议的商业应用 本文介绍的技术具有广泛的应用潜力。 涉及血液与异物表面的接触，包括 短期和长期使用的血管内装置和装置 体外循环心肺肾支持。

Platelet activation remains a problem in extracorporeal circulation. Researchers have recently shown that synthetic nitric oxide-releasing compounds (NO-RC) can be incorporated into a polymer matrix for localized delivery of nitric oxide (NO), a known inhibitor of platelet adhesion. The release of NO can be regulated by selecting NO-RC with specific half-lives, by varying the concentration of compound in the polymer, and by selecting polymers with desirable properties for the diffusion of water and NO. The proposed research will investigate the employment of this technology in coatings intended to prevent platelet adhesion to materials used in extracorporeal circulation. The chemical/polymer coating process described in this application allows for gradual sustained, and regulated release of very small quantities of NO at the polymer/blood interface, very similar to that which occurs at the normal endothelium boundary. An animal model will be used to correlate NO release and platelet adhesion to polymers. Several NO-RC will be investigated for NO release and antiplatelet efficacy while varying host polymer composition, NO-RC concentration, and blood flow. PROPOSED COMMERCIAL APPLICATION The technology described here has widespread potential in applicaitons that involve the contact of blood with foreign surfaces, including intravascular devices and devices used for short- and long-term extracorporeal cardiopulmonary and renal support.