TRAINING PROGRAM IN CARDIAC MUSCLE

对于心肌的研究来说，这是一个令人兴奋和充满活力的时代。这个 结构生物学、分子生物学和生物化学的交叉 有希望在描绘原子和原子结构方面取得快速进展 肌肉收缩的分子细节。发育生物学、遗传学 分子生物学正在产生快速的进展， 了解肌肉规范和发展的程序。这个 一些遗传性肌肉疾病的分子缺陷最近 已经被描绘出来，基因疗法正在探索中。 这一培训计划的基础是澳大利亚的医学院。 宾夕法尼亚大学提供了独特的环境 在心肌领域的研究和临床培训。最基本的 这一计划的研究方面借鉴了 宾夕法尼亚肌肉研究所、人类基因治疗研究所和 最近创建了肌肉和运动训练计划。这个 此应用程序中培训师的分布包括重要的 在医学院教职员工中的代表性在两个临床 和基础科学系。 这笔培训补助金旨在培养临床医生/科学家， 临床医生和研究科学家将成为新兴市场的领导者 分子心脏病学领域，特别强调心肌 发育、功能和疾病。我们请求适度的支持： 每年7名实习生。因为他们的兴趣范围和专业知识 这笔赠款上列出的培训师将证明，几乎所有重要的 目前心肌研究的领域由训练员负责。 列在这笔赠款上。培训人员使用的学科包括 分子生物学、遗传学、生物化学、结构生物学、细胞 生物学、发育生物学和生理学。这提供了 在心脏领域提供无与伦比的培训环境的潜力 肌肉生物学。

This is an exciting and dynamic time for the study of cardiac muscle. The intersections of structural biology, molecular biology and biochemistry hold the promise of rapid advancement in delineating the atomic and molecular details of muscle contraction. Developmental biology, genetics and molecular biology are yielding rapid advancements in the understanding of the program of muscle specification and development. The molecular defects of a number of inherited muscle diseases have recently been delineated and gene therapies are being explored. This training program is based in the School of Medicine of the University of Pennsylvania which provides a unique environment for research and clinical training in the area of cardiac muscle. The basic research aspects of this program draw upon the expertise of the Pennsylvania Muscle Institute, Institute for Human Gene Therapy, and the recently created Training Program in Muscle and Motility. The distribution of trainers in this application includes important representation in the faculty of the School of Medicine in both clinical and basic science departments. This training grant is designed to develop clinician/scientists, clinicians and research scientists who will be leaders in the emerging areas of molecular cardiology, with particular emphasis on cardiac muscle development, function and disease. We are requesting modest support: seven trainees per year. As the range of interests and expertise of the trainers listed on this grant will attest, virtually all of the important areas of current research in cardiac muscle are covered by the trainers listed on this grant. The disciplines utilized by the trainers include molecular biology, genetics, biochemistry, structural biology, cell biology, developmental biology, and physiology. This provides the potential for an unparalleled training environment in the area of cardiac muscle biology.