ENHANCED COLOR FLOW IMAGING OF BREAST CANCER

描述：(改编自调查员摘要)目标 本研究旨在提高慢性阻塞性肺疾病患者的诊断和治疗水平。 通过对乳腺癌的开发和评价更有效 超声彩色血流成像和定量技术。这 医学目标的实现要通过：1)进一步发展 获取、显示和量化血管和血管的方法 来自乳腺超声的脉冲回波信息；2)评估这些信息 超声在乳腺癌鉴别诊断中的方法和潜力； 3)在收购灵活性方面做出更多长距离的改进 和乳房超声成像的信息量。 多年来，在实现这些目标方面都取得了重大进展 01-03。已经开发了用于显示复杂血管和 灰度信息，以显示它们在3D和 量化在多普勒图像中提供给医生的内容。这个 功率模式成像作为一种医疗产品的引入受到了推动 通过我们在血容量和血流灌注量测量方面的建议和工作 这个项目的一部分，最初是1991年2月1日提出的。 用于已开发的3-D颜色的初步人体研究的数据获取 流量扫描、显示和量化已接近完成。 初步分析表明，三维可视化技术具有很好的应用前景 用于显示乳房区域的血管构筑 可见时，肿块及其与脉冲回声病变的关系。基于3D的 血管的视觉分级有助于乳房的辨别 癌症由灰度级信息提供，归一化，加权， 多普勒信号像素密度分辨能力更强。有建议说 为了更好地描述测量结果，请使成像更加全面 并将人体研究再延长1.5年，以增加 统计数据。少数恶性和良性病变将被 在微泡对比和没有微泡对比的情况下进行研究 评估3D颜色对局部晚期疾病的预测价值 血流超声对全身化疗的反应。 非常有希望的多视角(复合)3-D的初步演示 乳房血流和其他结构的成像已经完成 通过3-D图像集对齐和从点的共同配准中取消扭曲 以及在各种视图中手动发现的共同的线条。它是 建议将这一令人兴奋的远程技术发展带到 在04-06年度通过计算机化身份识别和 不同切面中同种组织体积的配准。至 方便获取乳房周围任何位置的3-D图像集 许多扫描头，我们最近展示的基于图像的扫描位置 将开发注册方法。

DESCRIPTION: (Adapted from investigator's abstract) The objective of this study is to improve the diagnosis and management of patients with breast cancer through development and evaluation of more effective techniques for ultrasound color flow imaging and quantification. This medical objective is to be accomplished by: 1) further developing methods for acquisition, display and quantification of vascularity and pulse echo information from breast ultrasound; 2) evaluating these methods and the potential of ultrasound in discriminating breast cancer; 3) making more long range improvements in the acquisition flexibility and information content of ultrasound imaging of the breast. Significant advances were made toward each of these objectives in Years 01-03. Methods have been developed for displaying complex vascular and gray scale information to show their relationships in 3D and for quantifying what is offered to the physician in the Doppler images. The introduction of power mode imaging as a medical product was motivated by our proposal and work on blood volume and perfusion measurement as part of this project, which was proposed initially February 1, 1991. Data acquisition for initial human studies of the developed 3-D color flow scanning, display and quantification is nearly complete. Preliminary analyses indicate that 3-D visualization is quite promising for displaying the vascular architecture of the region of the breast mass and its relation to the pulse echo lesion when visible. 3D-based visual ratings of vascularity contributed to the discrimination of breast cancer provided by gray scale information and normalized, power-weighted, Doppler signal pixel density discriminated every better. It is proposed to better characterize the measurements, make the imaging more versatile and extend the human studies for an additional 1.5 years to increase the statistics. A small number of malignant and benign lesions will be studied with and without microbubble contrast as will a group with locally advanced disease to assess the predictive value of 3-D color flow ultrasound for response to systemic chemotherapy. Very promising preliminary demonstrations of multiview (compound) 3-D imaging of breast blood flow and other structures have been accomplished by 3-D image set alignment and unwarping from coregistration of points and lines found manually to be in common in the various views. It is proposed to bring this exciting long range development of technology to a practical level in years 04-06 by computerized identification and registration of homologous tissue volumes in the different views. To facilitate acquisition of 3-D image sets anywhere round the breast with many scanheads, our recently-demonstrated image-based scan position registration approach will be developed.