Investigating the evolution of innate and adaptive cellular immunity

本提案旨在评估澳大利亚土著人口的地理和遗传隔离对适应性和先天免疫系统的影响。该项目将使用新的DNA测序方法来生成两个基因座的高分辨率序列，这两个基因座调节先天和适应性免疫反应，主要组织相容性复合体位点和杀伤细胞免疫球蛋白样受体位点。在最初的筛选中，确定了这些基因的不同变体和组合。该项目旨在探究这些关键基因的变异如何影响细胞毒性淋巴细胞的功能，为免疫识别机制的进化驱动提供见解。

This proposal aims to assess the impact of geographical and genetic isolation of the Australian Indigenous population on adaptive and innate immune systems. The project will use novel DNA sequencing approaches to generate the high resolution sequences of two genetic loci that regulate innate and adaptive immune responses, the major histocompatibility complex locus and the killer cell immunoglobulin-like receptor locus. In an initial screen, distinct variants and combinations of these genes were identified. This project aims to interrogate how variation in these critical genes impacts on the function of cytotoxic lymphocytes, providing insights into the evolutionary drivers of immune recognition mechanisms.