Improved models to understand the genomic architecture of complex traits

该项目旨在改进复杂性状的遗传学建模。该项目将开发和测试使用全基因组遗传数据的模型，以调查有多少遗传能力（遗传效应）是我们感兴趣的性状的基础，它位于基因组的哪个位置，以及有多少遗传能力在性状之间是共享的。新模型将在一个免费软件包的统计算法中实现。该项目旨在增加对生物机制的理解，遗传关联分析的效率和基因组预测的准确性，包括干预措施的效果。该项目将使人体模型适用于更广泛的生物体，特别是细菌。

This project aims to improve modelling of the genetics underlying complex traits. The project will develop and test models for using genome-wide genetic data to investigate how much heritability (genetic effect) underlies traits of interest, where it lies in the genome, and how much of it is shared across traits. The new models will be implemented in statistical algorithms in a freely-available software package. This project expects to increase understanding of biological mechanisms, the efficiency of genetic association analyses and the accuracy of genomic prediction, including the effects of interventions. The project will adapt human models to a wider range of organisms, in particular bacteria.