SUBPOPULATIONS OF MOTOR CORTICAL NEURONS IN LOCOMOTION

运动皮质网络中的神经元的特性已经产生 因为运动皮质之间的直接联系而引起了相当大的关注 激活和运动行为。锥体束神经元最多 运动皮质中众所周知的元素。然而，人们对此知之甚少。 其他主要运动皮质传出通路与神经传导功能的关系 与运动行为有关的神经元间分类。 这项工作的主要目标是检查 识别运动皮质网络中的元素(传出和 神经元亚群)对运动行为的影响。特别关注 将被给予一大群“沉默的”神经元 在清醒但被固定的受试者的传出神经元之间描述。 所有数据都将从经过训练的兔子身上获得 平坦的水平表面上的实验室，上坡和下坡 一种前肢和前肢都有重物的斜坡 形状各异的障碍物。 这些数据将为运动皮质的生理学提供一个独特的视角 在自由活动的动物的自然条件下研究的网络。 这种对运动皮质内已识别的亚群的分析已经 在任何物种中都没有进行过。

The properties of neurons in the motor cortical networks have generated considerable attention because of the direct link between motor cortical activation and motor behavior. The pyramidal tract neurons are the most well-known elements of the motor cortex. However, little is known about the relationship of other major motor cortical efferent pathways and interneuronal classes to motor behavior. The primary goal of this work is to examine the relationship of identified elements within the motor cortical networks (efferent and interneuronal subpopulations) to locomotor behavior. A special attention will be given to a large population of 'silent" neurons that have been described among efferent neurons in awake but immobilized subjects. All data will be obtained from rabbits trained to walk inside an experimental chamber on a flat horizontal surface, uphill and downhill on an incline, with weights attached to both forelimbs and overcoming obstacles of different shapes. The data will offer a unique view on the physiology of the motor cortical network studied under natural conditions of a freely behaving animal. Such an analysis of identified subpopulations within the motor cortex has not been performed in any species.