NEUROPHYSIOLOGICAL EVALUATION OF A MOTOR CONTROL MODEL

拟议项目的目的是评估大脑皮层的模型 通过一系列神经生理学实验进行运动控制。 测试的模型是基于一组不同的 生理、解剖和心理物理数据，特别是 重点关注大脑皮层4区和5区的细胞反应数据 自愿和被动的运动。因为该模型提出 不同神经区域的特定功能角色，它使特定的 在小说中对这些区域细胞反应的预测 实验范式。需要测试的特定假设包括 4区补药活动相当于下降的建议 组合位置和力信息的命令，以及 前部5区的紧张性活动对应于 当前肢体位置。这些假设做出了如下预测 任务期间4区和5区细胞反应的差异 它将力和位置信息与纯位置相分离 信息。提出了两种实验范式来检验这一点， 一种是比较等距运动和 一种是单摆运动，另一种是 障碍的存在。除了它与模型的相关性之外 经过测试，所获得的数据有望有助于理解 在自主运动过程中的皮质功能。

The purpose of the proposed project is to evaluate a model of cortical motor control through a series of neurophysiological experiments. The model tested has been developed based on a diverse set of physiological, anatomical, and psychophysical data, with particular focus on data about cell responses in cortical areas 4 and 5 during voluntary and passive movements. Because the model proposes specific functional roles to different neural regions, it makes specific predictions regarding cell responses in these regions during novel experimental paradigms. The particular hypotheses to be tested are the proposals that tonic activities in area 4 correspond to a descending command that combines both position and force information, and that tonic activities in anterior area 5 correspond to a representation of current limb position. These hypotheses make predictions regarding the difference in cell responses between areas 4 and 5 during tasks which dissociate force-and-position information from pure position information. Two experimental paradigms are proposed to test this, one involving a comparison between isometric movements and movements with a pendulum, the other involving movements in the presence of obstacles. Aside from its relevance to the model being tested, the data obtained is expected to contribute to the understanding of cortical function during voluntary movement.