CHRONOBIOLOGY OF PARTIAL EPILEPSY

内侧颞叶癫痫(MTLE)，最常见的部分性癫痫 癫痫，影响大多数癫痫患者的失控发作。 癫痫发作不是随机发生的，而是以每天的模式发生。研究表明， 研究表明，癫痫发作可在睡眠-觉醒转换时聚集或发生在 白天或夜间的模式。可能对时间安排的影响 癫痫发作包括睡眠-觉醒状态，外源性周期，如光- 暗周期，或生物钟的内生节律。因为 在人类身上测试这些影响很困难，可能的机制有 没有在严酷的条件下进行比较。它们之间的区别是 周期很重要，因为它们具有不同的生理功能和潜力 对癫痫发作时间的影响。理解时间上的影响 对癫痫的发生是确定以下因素的关键一步 允许表达癫痫发作。这项建议审查了时间 部分性癫痫动物模型中自发性边缘惊厥的分布 癫痫具有共同的临床、脑电和组织学特征 与人类MTLE相似。初步结果显示，边缘 癫痫发作以非随机的每日节律发生，类似于 MTLE。在这项研究中，我们将研究内源性昼夜节律的作用。 节律，通过运动活动和体温的标志来测量 癫痫发作的时机。我们将检验这些假设。 1)边缘癫痫发作和癫痫状态改变昼夜节律。 2)边缘癫痫发作的分布与睡眠-觉醒的阶段有关。 州政府。 3)边缘癫痫的发生受以下因素的影响 内源性的昼夜节律。 总而言之，研究结果将决定 促进部分癫痫发作的表达，并可能提供新的视角 用于治疗控制不佳的癫痫。

Mesial temporal lobe epilepsy (MTLE), the most common form of partial epilepsy, affects the majority of patients with uncontrolled seizures. Seizures do not strike randomly but occur in daily patterns. Studies have shown that seizures can cluster at sleep-wake transitions or occur in diurnal or nocturnal patterns. Possible influences on the timing of seizures include the sleep-wake state, exogenous cycles such as the light- dark cycle, or endogenous rhythms of the biological clock. Because of the difficulty in testing these influences in humans, possible mechanisms have not been compared under rigorous conditions. The distinctions among these cycles is important because of their different physiology and potential effects on the timing of seizures. Understanding the temporal influences on seizure occurrences is a critical step in determining the factors that permit expression of seizures. This proposal examines the temporal distribution of spontaneous, limbic seizures in an animal model of partial epilepsy that shares clinical, electrographic, and histological similarities with human MTLE. Preliminary results show that limbic seizures occur non-randomly in a daily rhythm similar to that found in MTLE. In this study we will examine the role of endogenous circadian rhythms, measured by markers of motor activity and body temperature, on seizure timing. We will test these hypothesis. 1) Limbic seizures and the epileptic state alter circadian rhythms. 2) The distribution of limbic seizures is tied to phases of the sleep-wake state. 3) Limbic seizure occurrence is influenced occurrence is influenced by endogenous, circadian rhythms. In summary, the results will determine the chronobiological factors that facilitate partial seizure expression and may provide new perspectives into treatments for poorly controlled epilepsy.