Capturing tissue-specific progenitors from embryos and stem cells

该项目旨在描绘胚胎中的前体细胞，这些前体细胞能够在体内形成主要的细胞类型。该项目将使用遗传分析来阐明支持这些前体细胞发生的关键遗传活动，并跟踪细胞分化的轨迹和范围。胚胎学知识将为产生细胞多样性的发育过程的基本原理提供见解，并使鉴定独特的前体和评估从干细胞中获得生物学相关细胞类型的功效成为可能。该项目预计将对组织工程和生物反应器技术的细胞生产方法的翻译产生重大影响。

This project aims to delineate the precursor cells in the embryo that give rise specifically to major cell types in the body. The project will use genetic analysis to elucidate the critical genetic activity that underpins the genesis of these precursor cells and to track the trajectory and the scope of cell differentiation. The embryological knowledge will provide insights into the fundamentals of developmental process for generating cellular diversity and enable identifying unique precursors and the evaluation of the efficacy of deriving the biological relevant cell types from the stem cells. This project expects to have a significant impact on the translation to cell production methodology for tissue engineering and bioreactor technology.