TRABECULAR ARCHITECTURAL EFFECTS ON MATERIAL PROPERTIES

描述：此应用程序的总体目标是调查 形态与建筑形态的关系 小梁骨和皮质骨及其力学性能。 这些调查旨在延长申请人的 未来检验骨细胞的全球假说的能力 通过细胞外基质层次化感知机械刺激 变形。长期目标是确定特定性质的特征 刺激骨细胞做出反应的机械因素。这个 本申请是先前工作的延伸，建议开发 用于估算应力和应变的实验和分析研究 骨细胞陷窝水平的分布。具体地说，具体的 目的是将骨小梁和皮质骨的力学性能联系起来 结构形态、骨龄和空间位置的特性 在骨子里；评估实验和理论上的误差 测量；并估计骨细胞周围的应变分布 腔隙。

DESCRIPTION: The overall objective of this application is to investigate the relationship between the morphology and architectural configuration of both trabecular and cortical bone and their mechanical properties. These investigations are directed towards extending the applicant's capabilities for future testing of a global hypothesis that bone cells sense mechanical stimulus through hierarchical extracellular matrix deformations. The long term goal is to characterize the specific nature of the mechanical factors which stimulate bone cells to respond. The present application, an extension of previous work, proposes to develop experimental and analytical studies to estimate stress and strain distributions at the osteocyte lacunae level. Specifically, the specific aims are to correlate the trabecula and cortical bone mechanical properties with structural morphology, bone age, and spatial location within the bone; assess the error in the experimental and theoretical measurements; and estimate the strain distributions around osteocyte lacunae.