THROMBOSIS MARKERS OVER TIME IN CARDIOVASCULAR DISEASE

拟议研究的目标是确定是否连续评估 心血管疾病（CVD）的新风险因素是一个重要的 作为预测老年队列中临床CVD事件的工具， 心血管健康研究。研究人员有令人兴奋的新数据 显示止血生物标志物的强相关性， 在表面健康的受试者中炎症与CVD风险增加 65岁以上这些独特的结果，沿着的结果，建议 研究，可能对心血管疾病的实践产生重大影响 药为了定义正常的纵向变化， 利息将在相隔三年的两个时间点进行衡量。一 以心肌梗死和心血管疾病死亡为研究对象的巢式病例对照研究 终点，将完成研究之间的关系 生物标志物和CVD风险的纵向变化。效果修改 将评估亚临床CVD。两个时间点的生物标志物水平 点将用于确定测量是否接近 心血管事件是一个重要的决定因素的预测效用的 标记。将开发和验证预测模型，以确定 未来CVD风险最高的老年人。候选人是 致力于成为心血管领域的独立研究者 流行病学沿着她优秀的医学背景， 为了实现她的目标，需要流行病学方面的专业知识， 生物统计学和分子生物化学和生理学。候选 已经开始在所有三个领域的培训，攻读硕士学位， 流行病学，研究老年人止血的流行病学， 并参与了一个著名的生物化学小组的研究。的 该奖项的目标是支持扩大知识和巩固 分子流行病学的所有三个关键领域，通过一个重要的 研究项目。这将有助于候选人的成功， 分子心血管流行病学拟议的环境 研究是理想的候选人的需要。赞助商，RP特雷西，a 临床化学家，作为一名分子流行病学家， 建立了一个以高精度而闻名的大型实验室， 生物标志物评估在许多流行病学研究中。他致力于 候选人，如申请中所示。共同申办方LH 库勒在心血管领域做出了广泛贡献 流行病学，并补充特雷西博士的技能。的专门知识 其他顾问是多样化的，并且与职业生涯相匹配 候选人的发展计划，以及研究的目的。 申请人成功的一个关键因素是 该机构对她的职业发展的承诺。

The goal of the proposed research is to determine if serial assessment of novel risk factors for cardiovascular disease (CVD) is an important tool in prediction of clinical CVD events in an elderly cohort, the Cardiovascular Health Study. The researchers have exciting new data showing strong associations of biomarkers of hemostasis and inflammation with increased CVD risk in apparently healthy subjects over 65. These unique results, along with results of the proposed research, may have a major impact on practice of cardiovascular medicine. To define normal longitudinal change, the biomarkers of interest will be measured at two time points three years apart. A nested case-control study with myocardial infarction and CVD death as endpoints, will be completed to study the relationship between longitudinal change of biomarkers and CVD risk. Effect modification by subclinical CVD will be assessed. Levels of biomarkers at the two time points will be used to determine whether proximity of measurement to CVD event is an important determinant of predictive utility of the markers. Prediction models will be developed and validated to identify older individuals at the highest risk of future CVD. The candidate is committed to becoming an independent investigator in cardiovascular epidemiology. Along with her excellent medical background, to accomplish her goal, expertise is required in epidemiology, biostatistics, and molecular biochemistry and physiology. The candidate has begun training in all three areas, pursuing a masters degree in Epidemiology, studying the epidemiology of hemostasis in the elderly, and participating in research with a notable biochemistry group. The goal of this award is to support expanded knowledge and solidification of all three key areas of molecular epidemiology, through an important research project. This will facilitate success of the candidate in molecular cardiovascular epidemiology. The environment for the proposed research is ideal for the candidate's needs. The sponsor, RP Tracy, a clinical chemist, has a significant role as a molecular epidemiologist, having built a large laboratory with a reputation for high-precision biomarker assessment in many epidemiologic studies. He is committed to the candidate, as demonstrated in the application. The cosponsor, LH Kuller, has contributed broadly to the field of cardiovascular epidemiology, and supplements the skills of Dr. Tracy. The expertise of the other advisors is diverse and well matched to the career development plans of the candidate, and to the aims of the research. A critical factor to the success of the applicant is the unequivocal commitment of the institution to her career development.