NONINVASIVE MYOCARDIAL MOTION ANALYSIS WITH MRI

描述：这是我们继续开展工作的一项建议 基于相位对比磁共振成像的心肌运动分析 (MRI)朝着改进的、非侵入性评估和 心肌缺血及其他心脏疾病患者的处理 病理学。我们已经成功地开发出一种技术，可以提取 使用以下方法获取的速度图中有关心肌动力学的信息 核磁共振成像提供了许多显著的优势，目前 可用的非侵入性方法，如超声波和核医学。 不透射线标志物的视频荧光摄影术和声学显微测量法，金 因其准确性和准确性而确定心脏运动的标准 他们研究单个心肌样本收缩的能力， 对今天人们所知的心肌动力学负有很大责任。 然而，这些技术具有高度侵入性，只能用于 研究目的。另一种MRI方法，心肌标记，与 我们的技术能够测量单个区域的运动和 已经提供了关于心肌生理学的基本信息。 我们的相衬技术有许多额外的优点，因为它 能够容易地研究整个心脏周期，以执行 回溯分析，绘制三维应变参数图 以前所未有的空间采样贯穿整个心脏。 拟议的工作是我们成就的直接延伸，并形成了 其中我们将：(1)开发多触发脉冲序列 不受来自运动和其他数据源的伪像的影响 不一致，这将在体内产生与 在体外表现出优异的能力，(2)开发和测试 从速度中提取和显示运动信息的高级方法 FIELDS，(3)在一组心脏移植患者体内验证这些方法 以前植入过放射不透明标志物的患者，以及(4)测试 心肌缺血动物模型的制作方法(顿抑心肌和 急性心肌梗死)。这些实验将证明我们的 在模型中量化区域和全局应变参数的能力 缺血性心脏病的症状。 最终，监测收缩功能的能力与 对血流灌注敏感的测量，应允许患者 根据治疗的风险和潜在收益进行分层 干预措施。随着这项工作的圆满完成，我们将拥有 验证了无创性评价技术的准确性。 心肌动力学，并将有一个独特的工具，可以传播 用于心脏生理学的临床和研究核磁共振研究 全球范围内的设置。

DESCRIPTION: This is a proposal for the continuation of our work on myocardial motion analysis with phase contrast Magnetic Resonance Imaging (MRI) toward the ultimate goal of improved, noninvasive evaluation and management of patients with myocardial ischemia and other cardiac pathologies. We have successfully developed a technique that extracts information about myocardial dynamics from velocity maps acquired using MRI which offers many significant advantages over other currently available noninvasive methods such as ultrasound and nuclear medicine. Videofluorography of radiopaque markers and sonomicrometry, the gold standards for determination of cardiac motion due to their accuracy and their ability to study the contraction of individual myocardial samples, are responsible for much of what is known today about myocardial dynamics. However, these techniques are highly invasive and can only be used for research purposes. Another MRI method, myocardial tagging, shares with our technique the ability to measure the motion of individual regions and has already contributed basic information about myocardial physiology. Our phase contrast technique has many additional advantages, since it has the capability to readily study the entire cardiac cycle, to perform retrospective analysis, and to map 3-dimensional strain parameters throughout the heart with unprecedented spatial sampling. The proposed work is a direct extension of our accomplishments and forms a cohesive program in which we will: (1) develop multi-shot pulse sequences that are immune to artifacts from motion and other sources of data inconsistency, and that will yield in vivo performance matching the excellent capabilities demonstrated in vitro, (2) develop and test advanced methods to extract and display motion information from velocity fields, (3) validate the methods in vivo in a group of cardiac transplant patients with previously implanted radiopaque markers, and (4) test the method in animal models of myocardial ischemia (stunned myocardium and acute myocardial infarction). These experiments will demonstrate our ability to quantify both regional and global strain parameters in models of ischemic heart disease. Ultimately, the ability to monitor contractile function, combined with measurements sensitive to perfusion, should allow patients to be stratified according to risk and potential benefit of therapeutic interventions. With the successful completion of this work, we will have validated the accuracy of the technique for the noninvasive evaluation of myocardial dynamics, and will have a unique tool that can be disseminated for the study of cardiac physiology in both clinical and research MRI settings worldwide.