CANNABINOID RECEPTOR PHARMACOLOGY AND BIOCHEMISTRY

描述：(申请人摘要) 这是授予Allyn Howlett博士的研究科学家奖，他拥有理工科学士学位 优等生，生物化学和药理学和毒理学博士。Dr。 豪利特是该系的终身教授。药理和 圣路易斯大学医学院的生理科学，一个大型的， 技术多学科系，研究兴趣在 心血管、内分泌和神经生理学及药理学。Dr。 豪利特的研究工作集中在药理上， CB1大麻素受体的生化和细胞调控。她 目的是保持一个活跃的研究实验室，在那里，学生们， 研究员和访问科学家可以交流想法并分享他们的 专业领域。为了实现这一目标，豪利特博士要求继续 为了给每个人留出充足的研究时间 从事研究项目并维持研究的个人 与其他科学家的合作。RSA还将促进继续 通过研究会议、短期课程和 与其他研究科学家交流。豪利特博士的研究 NIDA资助的两个R01赠款中描述了这些项目。“大麻素 受体结构-活性关系“研究受体-配体 相互作用(大麻素、氨基烷基吲哚、二十烷醇等 结构)，以努力定义高亲和力的要求 关联性和有效性，使药理上不同的激动剂和 可以确定或开发拮抗剂(CB1或CB2选择性)。这 项目涉及与合成、分析和 计算化学家。神经细胞和大脑中的大麻素受体 阐述了受体发出反应信号的机制。 通过G蛋白，以及细胞调节这一过程的机制 通过修饰受体的活性(例如，磷酸化， 棕榈酰化)和合成的调节，细胞定位，和 退化。

DESCRIPTION: (Applicant's Abstract) This is a Research Scientist Award for Dr. Allyn Howlett, who has a B.S. cum laude, in Biochemistry and Ph.D. in Pharmacology and Toxicology. Dr. Howlett is a tenured Professor in the Dept. Pharmacological and Physiological Science at Saint Louis University School of Medicine, a large, technically multidisciplinary department with research interests in cardiovascular, endocrine and neural physiology and pharmacology. Dr. Howlett's research effort is concentrated on the pharmacological, biochemical and cellular regulation of the CB1 cannabinoid receptor. Her intention is to maintain an active research laboratory in which students, fellows and visiting scientists can exchange ideas and share from their areas of expertise. Toward this goal, Dr. Howlett requests the continuation of this RSA in order to allow ample research time to attend to each individual working on the research project and to maintain research collaborations with other scientists. The RSA will also foster continued professional development through research meetings, short courses and communication with other research scientist. Dr. Howlett's research projects have been described in two NIDA-funded R01 grants. "Cannabinoid Receptor Structure-Activity Releationships" examines the receptor-ligand interaction (cannabinoid, aminoalkylindole, eicosanoid, and other structures) in an effort to define the requirements for high-affinity association and efficacy, such that pharmacologically distinct agonists and antagonist (CB1- or CB2-selective) can be determined or developed. This project involves close collaboration with synthetic, analytical, and computational chemist. "Cannabinoid Receptors in Neuronal Cells and Brain" addresses the mechanisms through which the receptor signals its response through G proteins, and the mechanisms whereby the cell regulates this activity through modification of the receptor (e.g., phosphorylation, palmitoylation) and regulation of synthesis, cellular localization, and degradation.