METABOLISM IN GAMMA-GLUTAMY1 TRANSPEPTIDASE DEFICT MICE

描述：主要研究者最近培育了小鼠， 缺乏g-谷氨酰转肽酶（以下简称GGT）， 谷氨酰胺循环和谷胱甘肽代谢中的关键酶。他 现在的目标是将这些GGT缺陷小鼠用于四个目的：1） 确定为什么缺陷小鼠在生长和性成熟方面滞后; 2）如果 缺陷型小鼠含有其他GGT样活性; 3）更充分地 表征GGT在谷胱甘肽和氨基酸代谢中的作用; 和4）检查GGT代谢途径在两种诱导的 疾病状态、半乳糖胺/内毒素诱导的肝损伤和 甲基汞代谢和毒性。

DESCRIPTION: The principal investigator has recently generated mice that lack g-glutamyl transpeptidase (hereafter referred to as GGT), a critical enzyme in the g-glutamy cycle and glutathione metabolism. He now aims to use these GGT- deficient mice for four purposes: 1) to determine why deficient mice lag in growth and sexual maturation; 2) if deficient mice contain other GGT-like activities; 3) to more fully characterize the role of GGT in glutathione and amino acid metabolism; and 4) to examine the role of GGT metabolic pathways in two induced disease states, galactosamine/endotoxin induced liver injury and methylmercury metabolism and toxicity.