CTL RESPONSE IN NON-B CLADE HIV1 INFECTION

描述：（改编自申请人摘要）本研究旨在帮助 开发一种有效的疫苗， 感染非B分支病毒的人群，通过定义相关方面 在非B分支株感染中观察到的免疫反应中， HIV-1，包括CTL交叉进化枝识别的详细检查。 待探讨的相关问题包括：a）评估CTL谱 塞内加尔非B进化枝感染者群体的反应 病毒，在急性和慢性感染中; B）鉴定最佳免疫原性 由非B进化枝特异性CTL识别的表位，并确定 这些表位的HLA限制，c）确定保守程度 或这些CTL与其它进化枝病毒，即A，B，C， D和E，和d）确定HIV-1特异性CTL克隆的能力 由非B进化枝感染产生，以抑制病毒复制， HIV-1进化枝。 a.候选人：该候选人获得了医学博士学位， 1990年，加州大学旧金山分校弗朗西斯科毕业， 两年半的临床和博士后研究， 马萨诸塞州综合医院。 B.申办者：布鲁斯步行者博士是一名医学副教授， 哈佛医学院和伙伴艾滋病研究中心主任 （马萨诸塞州总医院）。 C.环境：研究和培训将在 马萨诸塞州总医院，与哈佛大学合作 凯斯西储大学公共卫生学院 乌干达和塞内加尔。 D.培训计划：候选人将继续研究期间开始 在步行者博士的实验室做了两年研究员

DESCRIPTION: (adapted from applicant's abstract) This study aims to assist in the development of an effective vaccine that is appropriate for populations infected with non-B clade viruses, by defining relevant aspects of the immunological responses seen in infections by non-B clade strains of HIV-1, including detailed examination of CTL cross-clade recognition. Relevant issues to be explored include: a) evaluating the spectrum of CTL responses in defined Senegalese cohorts of persons infected with non-B clade viruses, in acute and chronic infection; b) identifying optimal immunogenic epitopes recognized by non-B clade specific CTLs and determining the HLA-restriction of these epitopes, c) determining the degree of conservation or cross-recognition of these CTLs with other clade viruses, namely A, B, C, D and E, and d) determining the ability of HIV-1-specific CTL clones generated from non-B clade infection to inhibit viral replication by other HIV-1 clades. a. Candidate: The candidate received her medical doctorate from the University of California at San Francisco in 1990, and has since completed two and a half years of clinical and post-doctoral fellowship at the Massachusetts General Hospital. b. Sponsor: Dr. Bruce Walker is an Associate Professor of Medicine at Harvard Medical School and Director of the Partners AIDS Research Center (Massachusetts General Hospital). c. Environment: The research and training will be carried out at the Massachusetts General Hospital, with collaborations involving the Harvard School of Public Health, Case Western Reserve University and groups in Uganda and Senegal. d. Training Plan: The candidate will continue research begun during the prior two years as a fellow in Dr. Walker's laboratory.