CHILDREN'S CANCER GROUP

这笔赠款的目的是促进 明尼苏达大学的调查人员在多个机构 合作的治疗性和非治疗性研究 儿童癌症组织(CCG)。在过去的五年里，该大学 明尼苏达大学一直保持其作为CCG领先机构的角色，两者 在后勤和科学上。自1983年以来，这一数字增长了50%。 明尼苏达大学安排研究的患者数量 网络，到1992年，预计一线将有超过125名新患者 研究和1117名患者将进行积极的随访，将 明尼苏达大学在CCG的33所主要院校中排名第三 两个类别都有。从科学上讲，明尼苏达大学的研究人员 在CCG研究的各个方面都处于领先地位，包括治疗 急性淋巴细胞性白血病、急性髓系白血病和神经母细胞瘤； 抗癌药物的新药开发及药代动力学研究； 骨髓移植治疗白血病、神经母细胞瘤等 儿童实体瘤；放射治疗，包括全身 放射；癌细胞的特性，包括细胞遗传学和 细胞表面抗原测定；癌症流行病学；研究 探讨儿童癌症的远期效应及其治疗。 21名明尼苏达大学调查人员对CCG持有立场 研究委员会、战略小组、科学委员会、纪律 委员会，或行政委员会。此外，其中15个 调查人员曾担任CCG多个委员会的主席， 记录明尼苏达大学是顶尖的CCG 在科学领导方面的机构。CCG研究使用 “团队方法”，涉及来自不同领域的个人 学科包括肿瘤学家、放射治疗师、外科医生、 免疫学家、病理学家、细胞遗传学家、药理学家和 流行病学家。明尼苏达大学的调查人员参与了 CCG感兴趣的几乎所有领域以及我们对未来CCG的参与 研究将继续增长。这笔赠款要求提供人员支持 明尼苏达州调查人员和人员维护有效的关键 CCG研究的数据管理和质量控制；明尼苏达州旅行 调查人员；以及管理我们继续进行的 参与科学投入和指导、规划、 临床研究和辅助研究的发展和进行 将由儿童癌症组织进行。

This grant is aimed at facilitating the continued involvement of investigators at the University of Minnesota in the multi-institutional cooperative therapeutic and non-therapeutic studies conducted by the Childrens Cancer Group (CCG). During the past five years, the University of Minnesota has maintained its role as a leading institution in CCG, both logistically and scientifically. Since 1983, there has been a 50% increase in the number of patients placed on study by the University of Minnesota network such that by 1992 over 125 new patients are expected on 1st line studies and 1,117 patients will be in active follow-up, placing the University of Minnesota third among CCG's 33 principal institutions in both categories. Scientifically, the University of Minnesota investigators have been leaders in various aspects of CCG studies, including treatment of acute lymphocytic leukemia, acute myeloid leukemia, and neuroblastoma; investigation of new agents and pharmacokinetics of anti-cancer drugs; bone marrow transplantation for leukemia, neuroblastoma, and other childhood solid tumors; radiation therapy, including total body irradiation; characterization of cancer cells, including cytogenetics and cell surface antigen determinations; cancer epidemiology; and studies investigating the late effects of childhood cancer and its treatment. Twenty-one University of Minnesota investigators hold positions on CCG study committees, strategy groups, scientific committees, discipline committees, or administrative committees. Furthermore, 15 of these investigators have been chairpersons of various CCG committees, documenting that the University of Minnesota is among the top CCG institutions in scientific leadership. CCG studies are conducted using a "team approach" which involves individuals from a wide range of disciplines including oncologists, radiation therapists, surgeons, immunologists, pathologists, cytogeneticists, pharmacologists, and epidemiologists. University of Minnesota investigators are involved in virtually all areas of CCG interest and our involvement in future CCG studies will continue to grow. This grant requests personnel support for Minnesota investigators and personnel key to the maintenance of effective data management and quality control for CCG studies; travel for Minnesota investigators; and miscellaneous expenses for administering our continued involvement in both scientific input and the direction, planning, development, and conduct of clinical investigation and ancillary studies to be conducted by the Childrens Cancer Group.