MECHANISM OF TIAR REPRESSION OF TIA1

该项目的长期目标是了解TIA-1的作用 和TIAR在细胞代谢中的作用。我们的工作假设是这些 蛋白质与特定的mRNAs亚群结合以调节其 翻译，也许是为了应对环境压力。建议数 项目将通过检查功能交互来促进这一目标 在完整细胞中，TIAR与其可能的TIA-1mRNA底物之间的作用。 对这种典型相互作用的分析将使我们能够评估 通过核苷酸同源性增加潜在的底物，以进一步提高我们的 了解这些RNA结合蛋白在其建议的作用 压力反应。

The long-term goal of this project is to understand the role of TIA-1 and TIAR in cellular metabolism. Our working hypothesis is that these proteins bind to specific subsets of mRNAs to regulate their translation, perhaps in response to environmental stress. The proposed project will promote this end by examining functional interactions between TIAR and its putative TIA-1 mRNA substrate in intact cells. Analysis of this prototypical interaction will enable us to assess additional potential substrates by nucleotide homology, to further our understanding of these RNA-binding proteins in their proposed role in the stress response.