MECHANISM OF TIAR REPRESSION OF TIA1

该项目的长期目标是了解TIA-1的作用 和TIAR在细胞代谢中的作用 我们的假设是 蛋白质与特定的mRNA亚群结合， 翻译，也许是对环境压力的反应。拟议 该项目将通过研究功能相互作用来促进这一目标 在完整细胞中TIAR与其假定的TIA-1 mRNA底物之间的关系。 对这种典型互动的分析将使我们能够评估 通过核苷酸同源性，进一步研究其他潜在底物， 了解这些RNA结合蛋白在它们的拟议作用， 压力反应

The long-term goal of this project is to understand the role of TIA-1 and TIAR in cellular metabolism. Our working hypothesis is that these proteins bind to specific subsets of mRNAs to regulate their translation, perhaps in response to environmental stress. The proposed project will promote this end by examining functional interactions between TIAR and its putative TIA-1 mRNA substrate in intact cells. Analysis of this prototypical interaction will enable us to assess additional potential substrates by nucleotide homology, to further our understanding of these RNA-binding proteins in their proposed role in the stress response.