DEVELOPMENT OF CORTICAL ORIENTATION COLUMNS

(1)总结：本项目的目标是明确机制 视网膜和LGN的输入通过它来指导出生后的 雪貂定向选择性的研究进展。这将是 通过(1)用河豚毒素阻断视网膜输出 在发育过程中和(2)防止来自LGN的轴突 通过破坏皮质亚板到达皮质。跟随 从这些操作中恢复，其效果将通过以下方式评估 成人的光学和单单元记录，并伴随着 大脑皮层解剖改变的评估。目标将是 来描述正常的相应生理功能的紊乱 神经反应特性的变化。

(1) Summary: the goal of this project is to define the mechanisms by which input from the retina and LGN directs the postnatal development of orientation selectivity in the ferret. This will be accomplished by (1) blocking retinal output with tetrodotoxin during development and (2) preventing axons from the LGN from reaching the cortex by destroying the cortical subplate. Following recovery from these manipulations,their effetcts will be assessed by optical and single unit recordings in the adult accompanied by an assessment of alterations in the cortical anatomy. The goal will be to describe disruptions in the normal corresponding physiological changes in neural response properties.