METALWORKING FLUIDS--PANCREATIC AND LIVER CANCER RISK

描述：(改编自《调查员摘要》) 汽车/全美汽车工人联合会(GM/UAW)46,000名汽车工人的队列是 迄今为止对接触金属加工液的工人进行的最大规模的研究。 最近将后续行动延长到1994年，增加了50% 死亡人数。已经进行了广泛的暴露评估。 胰腺癌之前在这个队列中进行了调查，发现它 与合成金属加工液密切相关，用于 磨削操作，OR=3.0，95%可信区间：1.2~7.5。合成液是 潜在的公共卫生问题，因为它们的使用正在扩大。但是，在 之前的分析、潜伏期和累积暴露是有限的，因为 合成液体直到20世纪70年代初才开始广泛使用，S。 另外十年的随访使胰腺癌的数量翻了一番 病例，以及增加对合成液体的累积暴露 一群人。胰腺和胰腺的标准化死亡率(SMR) 与最初的死亡率研究相比，肝胆癌的死亡率有所增加 (1940-1984)。胰腺癌风险的增加也在 黑人和女性，这是最近雇佣的两个工人亚群。 将对胰腺和胰腺进行单独的嵌套病例对照研究 肝胆癌。将与注册处联系以核实原因 两种癌症都会死亡。条件Logistic回归模型将适用 以评估暴露反应关系。这两种癌症都被认为 同样的提议有两个原因：器官的解剖结构相似， 生理关系，而职业健康文献表明 相关行业也存在类似的风险。

DESCRIPTION: (Adapted from Investigator's Abstract) The General Motors/United Auto Workers (GM/UAW) cohort of 46,000 autoworkers is the largest study to date of workers exposed to metalworking fluids (MWFs). Follow-up has recently been extended through 1994, with a 50% increase in the number of deaths. An extensive exposure assessment has been conducted. Pancreatic cancer was previously investigated in this cohort and found it to be significantly associated with synthetic metalworking fluids used in grinding operations, OR = 3.0, 95% CI: 1.2-7.5. Synthetic fluids are of potential public health concern because their use is expanding. However, in the previous analysis, latency and cumulative exposures were limited because synthetics fluids did not come into widespread use until the early 1970's. Another ten years of follow-up has doubled the number of pancreatic cancer cases, as well as increased cumulative exposure to synthetic fluid in the cohort. Standardized mortality ratios (SMRs) for both pancreatic and hepatobiliary cancer have increased from the initial mortality study (1940-1984). The elevated risk for pancreatic cancer was also seen in blacks and females, the two most recently hired subgroups of workers. Separate nested case-control studies will be conducted for pancreatic and hepatobiliary cancer. Registries will be contacted to verify the cause of death for both cancers. Conditional logistic regression models will be fit to estimate exposure response relationships. Both cancers are considered in the same proposal for two reasons: the organs share a close anatomic and physiologic relationship, and the occupational health literature suggests similar risks in related industries.