M AVIUM WALL STRUCTURES FROM AIDS PATIENTS

描述(改编自《调查员摘要》)：总体目标 美国国家卫生研究院的首席调查员拨款AI 37139将调查 脂阿拉伯甘露聚糖(LAM)在猪瘟病毒毒力和致病机制中的作用 肺结核和麻风病。截断结构变体的鉴定 在乙胺丁醇耐药菌株中的LAM提供了 PI和模型化合物，用于结构和功能研究，目的是 确定LAM在宿主-分枝杆菌相互作用中的相关性。这个 目前AIDS-FIRCA的建议是调查LAM的结构特征 来自不同的禽类分支杆菌复合体(MAC)的临床和实验室菌株 在菌落形态和耐药性方面。具体地说，该提案将 菌落形态、毒力和耐药性的地址关系 通过从MAC中定义LAM的化学性质，通过检验 乙胺丁醇对MAC细胞壁中阿拉伯糖生物合成的影响 区分毒力和无毒的生化标记的研究 分离株。

DESCRIPTION (Adapted from the Investigator's Abstract): The overall aim of the U.S. Principal Investigator's NIH Grant AI 37139 is to investigate the role of lipoarabinomanan (LAM) in the virulence and pathogenesis of tuberculosis and leprosy. Identification of truncated structural variants of LAM in ethambutol drug-resistant strains of mycobacteria has provided the PI with model compounds for both structural and functional studies aimed at defining the relevance of LAM in host-mycobacterial interactions. The present AIDS-FIRCA proposal is to investigate the structural features of LAM from clinical and laboratory strains of M. avium complex (MAC) that differ in colony morphology and drug resistance. Specifically, the proposal will address relationship of colony morphotypes, virulence and drug reasistance by defining the chemical nature of LAM from MAC, by examinig the effect of ethambutol on the arabinan biosynthesis in the cell wall of MAC, and by studying the biochemical markers that distinguish virulent and avirulent isolates.