MRI IDENTIFICATION OF FIBROUS CAP ATROPHY AND RUPTURE

纤维帽的破裂是导致 晚期患者管腔表面血栓栓塞症并发症 动脉粥样硬化斑块。为斑块奠定基础的因素 破坏包括进行性帽子萎缩伴细胞丢失和 矩阵。不幸的是，这些信念很难检验，因为缺乏 动物模型。我们建议通过以下方式解决这个问题 结合人体组织和动物模型的跨学科方法 对可能支持这一过程的分子途径的研究。在这 项目中，我们将研究，使用高分辨率磁共振 影像，一组中度颈内动脉疾病患者 狭窄。我们将检验这样一种假设，即这些细胞的纤维帽 病变一般较厚，帽状突起变薄 斑块扩大，管腔变窄。我们还将确定 无论是缺血性神经事件还是斑块破裂 切除斑块的组织学评价与纤维帽的相关性 变薄了。

The rupture of the fibrous cap is the critical event leading to thromboembolic complications on the luminal surface of advanced atherosclerotic plaques. The factors that set the stage for plaque disruption include progressive cap atrophy with loss of cells and matrix. Unfortunately, these beliefs are hard to test because of a lack of animal models. We propose to solve this problem by an interdisciplinary approach combining human tissue and animal model studies of molecular pathways that could underlie this process. In this project, we will study, using high-resolution magnetic resonance imaging, a cohort of patients with moderate internal carotid artery stenosis. We will test the hypothesis that the fibrous caps of these lesions generally are thick and that thinning of the cap develops after the plaque enlarges and the lumen narrows. We will also determine whether ischemic neurological events or plaque rupture assessed by histological evaluation of excised plaques correlates with fibrous cap thinning.